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Detail Information
  1. Top
  2. Cell Culture
  3. Animal Cell Culture
  4. Cytokine / Growth Factor
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  6. PDGF-BB, Human, recombinant
  1. Top
  2. Cell Culture
  3. Animal Cell Culture
  4. Cytokine / Growth Factor
  5. Human, Recombinant Cytokines
  6. PDGF-BB, Human, recombinant
  1. Top
  2. Cell Culture
  3. Stem Cell Culture
  4. Cytokine / Growth Factor
  5. Human, Recombinant Cytokines
  6. PDGF-BB, Human, recombinant

PDGF-BB, Human, recombinant

for Biochemistry
Manufacturer :
FUJIFILM Wako Pure Chemical Corporation
Storage Condition :
Keep at -20 degrees C.
Citations (1)
PubMed Central® search
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SDS
Comparison
Product Number
Package Size
Price
Availability
Certificate of Analysis
Purchase
Distributor
166-19743
Barcode No
4548995010971
1mg
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Distributor
Distributor
160-19741
Barcode No
4987481387249
10ug
List Price
429.00 USD

In stock in Japan
Distributor

※Check  availability  in the US with the distributor.

Document

SDS
Product Specification Sheet
Spectral Data
Certificate of Analysis
Calibration Certificate

Application

Overview / Applications

Outline This product is for research use only. Do not administer it to human.

Platelet-derived growth factor (PDGF) was initially discovered as a molecule found in platelet α-granules that promoted the proliferation of mesenchymal cells. It is now known that PDGF is produced by many kinds of cells other than platelets and possesses a wide range of biological properties.
In vitro, PDGF-BB, PDGF dimer, promotes chemotaxis in white blood cells as well as proliferation of vascular smooth muscle cells, fibroblasts and capillary endothelial cells. Clinical application of PDGF is being investigated after it has been recently found that the molecule is involved in atherosclerosis as well as angiogenesis and metastasis of solid tumors.


[References]

  1. Heldin,C.-H. et al. : Proc. Natl. Acad. Sci. USA, 76, 3722 (1979)
  2. DallaFavera, R., et al. : Science, 218, 686 (1982)
  3. Collins,T., et al.: Nature, 316, 748 (1985)
  4. Ross, R., et al.: Science, 248, 1009 (1990)

PDGF was found as a growth factor for mesenchymal cells contained in the platelet alpha granule. It is now known to be produced by various cells other than platelets and to have a wide range of biological activities. PDGF-BB, a PDGF dimer, promotes the growth of vascular smooth muscle, fibroblasts and capillary endothelial cells and exhibits leukocyte migration action in vitro. Its clinical application has been studied because it has been found to be involved in arteriosclerosis, and vascularization and metastasis in solid cancer.

Property

Origin / Source E.coli expressed human PDGF-BB
Purity Bacterial endotoxins : <0.1ng/ug

Manufacturer Information

Alias

  • rhPDGF-BB
    Platelet-derived Growth Factor-BB, Human, recombinant

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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