Trichostatin A
- for Cellbiology
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
- CAS RN® :
- 58880-19-6
- Molecular Formula :
- C17H22N2O3
- Molecular Weight :
- 302.37
- GHS :
-
- Structural Formula
- Label
- Packing
- SDS
Comparison
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Product Number
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Package Size
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Price
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Availability
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Certificate of Analysis
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Purchase |
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1mg
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In stock in Japan |
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5mg
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In stock in Japan |
※Check availability in the US with the distributor.
Document
Application
Overview / Applications
Outline | This product is for research use only. Do not administer it to human.
HDAC inhibitors show connections with cell division cycles and differentiation, as well as with antitumor activity and apoptosis-inducing activity through the inhibition of the deacetylating activity of HDAC. They can be used for studies on cellular functions involving histone deacetylase. [Product List]M344 (Wako Cat. #139-14671 (1 mg)) Inhibitor of HDAC Class I and II. Structure homologue of Trichostain A.ITSA1 (Wako Cat.#093-05251 (5 mg)) Inhibitor of Trichostatin A.MC 1293 (Wako Cat.#136-14681 (5 mg)) Inhibitor of HDAC1 and maize deacetylase.MS-275 (Wako Cat.#132-14661 (1 mg)) Inhibits HDAC1 and HDAC3 but does not affect HDAC8.Piceatannol (Wako Cat.#169-21661 (10 mg)) Activator of HDAC Class III and inhibitor of kinase Syk.Sirtinol (Wako Cat.#197-13671 (5 mg)) Inhibitor of HDAC Class III. Cell-permeable.Splitomicin (Wako Cat.#190-13661 1 mg)) Inhibitor of HDAC Class III. Cell-permeable.Trichostatin A (Wako Cat.#200-11993 (1 mg); #204-11991 (5 mg)) Potent and reversible inhibitor of HDAC Class I and II.Valproic Acid (Wako Cat.#227-01071 (5 g); #225-01072 (25 g)) Inhibitor of HDAC1. Trichostatin A (TSA), a Streptomyces product, specifically inhibits the cell cycle of normal rat fibroblasts in the G1 and G2 phases at very low concentrations as reported by Yoshida, et al.TSA-induced G2-arrest induces the formation of proliferative tetraploid cells.In addition, nanomolar concentration of TSA have been shown to cause an accumulation of highly acetylated histones in vivo, and markedly inhibit the activity of partially purified histone deacetylase in vitro.TSA appears to be a useful product for researching the multiple functions of histone acetylation in regulatory mechanisms of eukaryotic cell proliferation and differentiation. Solubility: Soluble in methanol (1mg/10mL), ethanol, acetone, and water.
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Property
Appearance | Film |
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Origin / Source | Streptomyces sp. |
Manufacturer Information
Alias
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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