CultureSure® A-83-01
- for Cell Culture
- Specification Assay :
- 98.0+% (HPLC)
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
- CAS RN® :
- 909910-43-6
- Molecular Formula :
- C25H19N5S
- Molecular Weight :
- 421.52
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- Structural Formula
- Label
- Packing
- SDS
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Comparison
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Certificate of Analysis
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2mg
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In stock in Japan |
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10mg
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In stock in Japan |
※Check availability in the US with the distributor.
Document
Application
Overview / Applications
| Outline | This product is for research use only. Do not administer it to human. This is a selective inhibitor of TGF-β type II/activin receptor-like kinase (ALK5), type I activin/nodal receptor-like kinase (ALK4), and type I nodal receptor-like kinase (ALK7). It inhibits Smad2/3 phosphorylation, and inhibits TGF-β induced epithelial to mesenchymal transformation. It exerts almost no effect on bone morphogenetic protein type I receptor, p38 MAP kinase, and extracellular signal-regulated kinase. Furthermore, it has been reported that when added to rat iPS cell culture medium, it facilitates uniform growth of rat iPS cells without differentiation, and can be cultivated over a long period. [Li, W. Cell, 4, 16 (2009).] |
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| Precautions for Use | Packed on inactive gas |
Property
| Appearance | White - yellow, crystalline powder - powder or mass |
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| Purity | Bacterial endotoxins : <0.01EU/mg |
Manufacturer Information
Alias
- 1H-Pyrazole-1-carbothioamide, 3-(6-methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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