PD98059
- for Biochemistry
- Specification Assay :
- 95.0+% (HPLC)
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
- CAS RN® :
- 167869-21-8
- Molecular Formula :
- C16H13NO3
- Molecular Weight :
- 267.28
- GHS :
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- Structural Formula
- Label
- Packing
- SDS
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5mg
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In stock in Japan |
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Document
Application
Overview / Applications
| Outline | Mitogen Activated Protein Kinaze(MAPK)-1 inhibitor.The product has been reported to inhibit MAP kinase activation by insulinand block completely the increase in cell growthand MAP activity induced by leptin (obesity regulating hormone).The resting cell pretreated with PD-98059 has been demonstrated to inhibit a great deal the expression of the advance early genes c-fos and eggr-1 induced by a peroxisome proliferative agent. MAP (Mitogen Activated Protein) kinase (MAPK) is a kind of serine/threonine kinase that is activated by stimuli including extracellular stress, especially cell proliferation and differentiation. It is present in any eukaryote and plays a key role in various signal transduction pathways. Three types of kinases, according to phosphorylation, i.e. MAPK, MAP kinase kinase (MAPKK), and MAP kinase kinase kinase (MAPKKK) are known. In recent years, related cascades have been found, including p38MAPK, JNK, MEK1/2 and ERK3/5 cascades, which are the focus of detailed research. Research for ES/iPS cell Reagents for ES cell culture and iPS cell induction
MAPK Inhibitor Promotes self propagation of embryonic stem cells. Reference:
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Property
| Appearance | Pale yellow - yellowish brown, crystalline powder - powder or mass |
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| Melting Point | 164 - 165 degrees C |
Manufacturer Information
Alias
- 2'-AMINO-3'-METHOXYFLAVONE
2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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