Anti Rabbit Podoplanin, Monoclonal Antibody (PMab-32)
- for Immunochemistry
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
- Source :
- Rabbit
- Host :
- Mouse
- Clone No. :
- PMab-32
- Classification :
- Monoclonal
- Structural Formula
- Label
- Packing
- SDS
Comparison
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100ug
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In stock in Japan |
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Document
Overview
Podoplanin, a single-transmembrane glycoprotein, has been known as a marker of lymphatic endothelium and alveolar epithelium. And also known to be overexpressed in brain tumor, malignant mesothelioma, testicular tumor, and various squamous cell carcinomas. Its expression is associated with poor prognosis of some kinds of tumors.
Podoplanin has a highly conserved region, called PLAG domain, in its extracellular N-terminal region. In particular, podoplanin has been known to bind to CLEC-2, a receptor on the platelet, via PLAG3 domain sequence and sialylated O-glycan on PLAG3, inducing platelet aggregation. The platelet aggregation activity has been reported to be involved in metastatic and proliferation of cancer cells.
This is the first monoclonal antibody generated against rabbit podoplanin.
- Clone No.: PMab-32
- Source: Mouse
- Isotype: IgG1∙κ
- Antibody concentration: Approximately 1 mg/mL (indicated on the label)
- Cross-reactivity: Rabbit
- Specificity: Rabbit podoplanin
- Formulation: Liquid/PBS containing sodium azide
- Application: Western blot (from 1 μg/mL)
ELISA
Flow cytometry (from 1 μg/mL)
Immunohistochemistry (from 1 μg/mL)
※Please determine optimum experimental conditions for your application.
References
- Honma, R. et al., Monoclon. Antib. Immunodiagn. Immunother., 35(1), 41-47 (2016).
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Honma, R. et al., Monoclon. Antib. Immunodiagn. Immunother., 35(2), 65-72 (2016).
Property
Appearance | Solution |
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Composition | PBS. Contains sodium azide. |
Concentration | Protein : 1.0mg/mL |
Antibody Information
Antigen | Podoplanin |
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Antigen Alias | Podoplanin HT1A-1 OTS8 PA2.26 PSEC0025 T1-ALPHA T1A T1A-2 PDPN podoplanin, transcript variant 1 GP36, T1A-2, GP40, Gp38, PA2.26, OTS8,T1A, HT1A-1 Podoplanin (PDPN) AGGRUS GP36 GP38 GP40 |
Subclass | IgG1,k |
Labeling | Unlabeled |
Manufacturer Information
Alias
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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