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Valproic Acid

for Biochemistry
Specification Assay :
98.0% - 102.0% (Titration)98.0+% (Capillary GC)
Manufacturer :
FUJIFILM Wako Pure Chemical Corporation
Storage Condition :
Keep at RT.
Molecular Formula :
Molecular Weight :
  • Structural Formula
  • Label
  • Packing
Product Number
Package Size
Barcode No
List Price
JPY 4,200

In stock in Japan

Barcode No
List Price
JPY 14,300

In stock in Japan


Product Specification Sheet
Spectral Data
Certificate of Analysis
Calibration Certificate


Overview / Applications

Outline Antiepileptic. It has an activity enhancing effect on the GABA nerve system.
This product is for research use only. Do not administer it to human.

Cell Biological ResearchFor Research on Cell Cycle and TranscriptionHistone Deacetylase (HDAC) InhibitorsHistone deacetylase (HDAC) plays a central role in chromatin structure formation associated with the nuclear distribution of DNA. There are presently 17 known types of this enzyme in mammals, which are classifiedinto 3 classes (see table below). Also, HDAC Class III has been reported to be associated with regulation of aging and life span.

  • Mammalian HDAC Class I: Localized in the nucleus. Is similar to RPD3 enzyme. [Types : HDAC1-3, 8]
  • Mammalian HDAC Class II: Localized in the nucleus and cytoplasm and shuttles between the two. Similar to HDA1 enzyme. [Types: HDAC4-7, 9, 10]
  • Mammalian HDAC Class III: NAD-dependent enzyme. Localized in the nucleus and cytoplasm. Also called Sirtuin and is similar to SIR2 enzyme. [Types : Sirt 1-7]

HDAC inhibitors show connections with cell division cycles and differentiation, as well as with antitumor activity and apoptosis-inducing activity through the inhibition of the deacetylating activity of HDAC. They can be used for studies on cellular functions involving histone deacetylase.

[Related Products]

  • Piceatannol (Wako Cat.#169-21661 (10 mg)) Activator of HDAC Class III and inhibitor of kinase Syk.

  • Sirtinol (Wako Cat.#197-13671 (5 mg)) Inhibitor of HDAC Class III. Cell-permeable.

  • Trichostatin A (Wako Cat.#203-17561 (1 mg); #209-17563 (5 mg)) Potent and reversible inhibitor of HDAC Class I and II.

  • Valproic Acid (Wako Cat.#227-01071 (5 g); #225-01072 (25 g)) Inhibitor of HDAC1.

Research for ES/iPS cell
Reagents for ES cell culture and iPS cell induction
  • Maintain ES & iPs cells in an undifferentiated state

  • Improve reprogramming efficiency

Histone deacetylase Inhibitor

Enhances efficiency of iPS cell induction by Oct4, Klf4 and Sox2.


  1. Huangfu, D., et al.: Nature Biotechnol., 25, 1269 (2008)


Appearance Colorless - yellowish brown, clear liquid
Boiling Point about 220 degrees C
Density 0.903 - 0.908g/ml (20 degrees C)
Refractive Index 1.423 - 1.427(20 degrees C/D)

Manufacturer Information


For research use or further manufacturing use only. Not for use in diagnostic procedures.

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