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PD98059

for Biochemistry
Specification Assay :
95.0+% (HPLC)
Manufacturer :
FUJIFILM Wako Pure Chemical Corporation
Storage Condition :
Keep at -20 degrees C.
CAS RN® :
167869-21-8
Molecular Formula :
C16H13NO3
Molecular Weight :
267.28
GHS :
  • Structural Formula
  • Label
  • Packing
SDS
Comparison
Product Number
Package Size
Price
Inventory
Distributor
169-19211
Barcode No
4987481372276
5mg
List Price
JPY 26,600

In stock in Japan

Document

SDS
Product Specification Sheet
Spectral Data
Certificate of Analysis
Calibration Certificate

Application

Overview / Applications

Outline Mitogen Activated Protein Kinaze(MAPK)-1 inhibitor.The product has been reported to inhibit MAP kinase activation by insulinand block completely the increase in cell growthand MAP activity induced by leptin (obesity regulating hormone).The resting cell pretreated with PD-98059 has been demonstrated to inhibit a great deal the expression of the advance early genes c-fos and eggr-1 induced by a peroxisome proliferative agent.
MAP (Mitogen Activated Protein) kinase (MAPK) is a kind of serine/threonine kinase that is activated by stimuli including extracellular stress, especially cell proliferation and differentiation. It is present in any eukaryote and plays a key role in various signal transduction pathways. Three types of kinases, according to phosphorylation, i.e. MAPK, MAP kinase kinase (MAPKK), and MAP kinase kinase kinase (MAPKKK) are known. In recent years, related cascades have been found, including p38MAPK, JNK, MEK1/2 and ERK3/5 cascades, which are the focus of detailed research.
Research for ES/iPS cell
Reagents for ES cell culture and iPS cell induction
  • Maintain ES & iPs cells in an undifferentiated state

  • Improve reprogramming efficiency

MAPK Inhibitor

Promotes self propagation of embryonic stem cells.

Reference:

  1. Burdon, T., et. al.: Dev. Biol., 210, 30 (1999)

  2. Hamazaki, T., et. al.: Mol. Cell. Biol., 26, 7539 (2006)

Property

Appearance Pale yellow - yellowish brown, crystalline powder - powder or mass
Melting Point 164 - 165 degrees C

Manufacturer Information

Alias

  • 2'-AMINO-3'-METHOXYFLAVONE
    2-(2-AMINO-3-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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