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Talking of LAL

Apr, 2021

Kinetic Turbidimetric Assay (Onset time method)

This article was written by Dr. Masakazu Tsuchiya, FUJIFILM Wako Pure Chemical Corporation, for Vol. 59, No. 3 (October 1991) of Wako Junyaku Jiho.
The content of this article is from the time of publication. It is not the latest information due to new knowledge and changes in regulatory rules after original publication.

The kinetic turbidimetric assay (Onset time method) is listed as the Kinetic-Turbidimetric Technique in FDA Guidelines1) and is now widely used as part of Limulus test. Our Toxinometer® is a specializ...

Apr, 2021

Talking of LAL

Types of Limulus Tests

This article was written by Dr. Masakazu Tsuchiya, FUJIFILM Wako Pure Chemical Corporation, for Vol. 59, No. 2 (August 1991) of Wako Junyaku Jiho.
The content of this article is from the time of publication. It is not the latest information due to new knowledge and changes in regulatory rules after original publication.

Although many methods for the Limulus tests have been reported, the following 3 methods are currently widely used: 　(1) Gel-clot Method 1, 2) 　(2) Kinetic Turbidimetric Assay (Onset time method) 3, 4,...

Apr, 2021

Talking of LAL

Specificity of LAL

This article was written by Dr. Masakazu Tsuchiya, FUJIFILM Wako Pure Chemical Corporation, for No. 4 (March 1991) of Wako Junyaku Jiho.
The content of this article is from the time of publication. It is not the latest information due to new knowledge and changes in regulatory rules after original publication.

Limulus Amebocyte Lysate (LAL) reacts to both endotoxin and (1→3)-β-D-glucan. In 1981, Kakinuma et al. reported the reaction of carboxymethylated (1→3)-β-D-glucan(CMPS) to LAL1), and in the same year,...

Apr, 2021

Talking of LAL

What is Endotoxin?

This article was written by Dr. Masakazu Tsuchiya, FUJIFILM Wako Pure Chemical Corporation, for No. 2 (October 1990) of Wako Junyaku Jiho.
The content of this article is from the time of publication. It is not the latest information due to new knowledge and changes in regulatory rules after original publication.

Endotoxin (also known as lipopolysaccharide or LPS) is a type of pyrogen which possesses various biological activities, and is found in the outer membrane of Gram-negative bacteria. Due to its strong ...

Apr, 2021

Talking of LAL

What is LAL (Limulus Amebocyte Lysate)?

This article was written by Dr. Masakazu Tsuchiya, FUJIFILM Wako Pure Chemical Corporation, for No. 1 (July 1990) of Wako News.
The content of this article is from the time of publication. It is not the latest information due to new knowledge and changes in regulatory rules after original publication.

Ever since Levin and Bang discovered that endotoxin causes the coagulation of Limulus Amebocyte Lysate (LAL)1) , the Limulus test, which applies this phenomenon, has been used in endotoxin detection. ...

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Talking of LAL

Kinetic Turbidimetric Assay (Onset time method)

Types of Limulus Tests

Specificity of LAL

What is Endotoxin?

What is LAL (Limulus Amebocyte Lysate)?

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