Wako Blog

We introduce a wide range of topics of research, technical reports, tips on experiments and so on.

Front line of Neurodegenerative Diseases Research

Front line of Neurodegenerative Diseases Research

Vol.7 Amyotrophic lateral sclerosis (ALS)

This article was written by Dr. Seiji Watanabe and Dr. Koji Yamanaka, Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by upper motor neuron degeneration in the motor area of the cerebral cortex as well as lower motor neuron d...

Front line of Neurodegenerative Diseases Research

Vol.6 α-Synuclein in Parkinson's Disease

This article was written by Dr. Norihito Uemura, Department of Neurology, Graduate School of Medicine, Kyoto University.

Parkinson's disease (PD) is pathologically characterized by dopaminergic neuronal loss in the substantia nigra pars compacta and formation of neuronal inclusion called Lewy body. The significance of t...

Front line of Neurodegenerative Diseases Research

Vol.5 Overview of Parkinson's Disease

This article was written by Dr. Hodaka Yamakado, Department of Neurology, Graduate School of Medicine, Kyoto University

Parkinson's disease (PD) is a neurodegenerative disease clinically characterized by Parkinson symptoms and pathologically characterized by Lewy bodies and dopaminergic neuronal death.

Front line of Neurodegenerative Diseases Research

Vol.3 Amyloid β in Alzheimer's Disease

This article was written by Dr. Yukiko Hori and Dr. Taisuke Tomita, Laboratory of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo

A senile plaque, one of characteristic brain pathological features of Alzheimer's disease (AD), is the brain parenchymal accumulation of abnormally aggregating insoluble proteins forming amyloid fibri...

Front line of Neurodegenerative Diseases Research

Vol.2 Tau protein in Alzheimer's disease

This article was written by Dr. Masato Hasegawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science.

Alzheimer's disease (AD) is neuropathologically characterized by two abnormal structures: senile plaques and neurofibrillary tangles. Senile plaques are extracellular structures composed of amyloid β ...

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