Wako Blog

We introduce a wide range of topics of research, technical reports, tips on experiments and so on.

Front Line of Microglia Research

Front Line of Microglia Research

4th review: Macrophages control the inflammation and subsequent neural repair after ischemic stroke

This article was written by Dr. Kento Otani1,2, and Dr. Takashi Shichita1,3.

Cerebrovascular disease (stroke) is a major cause of chronic functional deficits, such as being bedridden. Ischemic stroke comprises approximately 80% of cerebrovascular disease in Japan. In ischemic ...

Front Line of Microglia Research

3rd review: Phagocytic cells in the brain

This article was written by Rena Kono, Yuji Ikegaya, and Ryuta Koyama, Graduate School of Pharmaceutical Sciences, The University of Tokyo.

Phagocytosis is an important process in the immune system. Exogenous viruses and pathogens as well as endogenous cell debris and abnormally aggregated proteins are removed by phagocytes, "professional...

Front Line of Microglia Research

2nd review: Origin of microglia and brain diseases

This article was written by Dr. Kazuyuki Takata, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University.

Microglia are tissue macrophages in the central nervous system (CNS) (i.e., brain and spinal cord) and play a frontline role in CNS immunity. With its unique developmental mode and biology being revea...

Front Line of Microglia Research

1st review: Neuropathic pain

This article was written by Dr. Makoto Tsuda, Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University.

In response to harmful stimuli, pain occurs in the body through the nociceptive system to trigger defensive behavior. However, chronic pain called neuropathic pain occurs when the nervous system is da...

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