Front Line of Microglia Research

6th review: Control of stroke via microglia-astrocyte crosstalk

This article was written by Dr. Schuichi Koizumi, Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi.

The roles of glial cells in brain function have been successively clarified. Given rapid, substantial, and various changes in glial cells in various brain diseases, it is assumed that these changes in...

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Front Line of Microglia Research

4th review: Macrophages control the inflammation and subsequent neural repair after ischemic stroke

This article was written by Dr. Kento Otani^1,2, and Dr. Takashi Shichita^1,3.

Cerebrovascular disease (stroke) is a major cause of chronic functional deficits, such as being bedridden. Ischemic stroke comprises approximately 80% of cerebrovascular disease in Japan. In ischemic ...

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Front Line of Microglia Research

3rd review: Phagocytic cells in the brain

This article was written by Rena Kono, Yuji Ikegaya, and Ryuta Koyama, Graduate School of Pharmaceutical Sciences, The University of Tokyo.

Phagocytosis is an important process in the immune system. Exogenous viruses and pathogens as well as endogenous cell debris and abnormally aggregated proteins are removed by phagocytes, "professional...

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Front Line of Microglia Research

2nd review: Origin of microglia and brain diseases

This article was written by Dr. Kazuyuki Takata, Division of Integrated Pharmaceutical Sciences, Kyoto Pharmaceutical University.

Microglia are tissue macrophages in the central nervous system (CNS) (i.e., brain and spinal cord) and play a frontline role in CNS immunity. With its unique developmental mode and biology being revea...

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Front Line of Microglia Research

1st review: Neuropathic pain

This article was written by Dr. Makoto Tsuda, Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University.

In response to harmful stimuli, pain occurs in the body through the nociceptive system to trigger defensive behavior. However, chronic pain called neuropathic pain occurs when the nervous system is da...

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