Amyloid β Antibody

Aβ is accumulated in the brain tissue of Alzheimer's disease patients. The accumulation of Aβ called "Senile plaque" can be observed in the tissue by staining with Aβ specific antibody. Aβ or Aβ polymerized Aβ oligomer is considered as a possible factor of Alzheimer's disease, therefore there are some research projects targeting Aβ. We offer various Aβ specific monoclonal antibodies which are developed by Takeda Pharmaceutical, Ltd. These antibodies have been used by many researchers, and used in several papers.

Aβ antibody Selection Guide

Wako Cat. No. 10 μL 017-26871 014-26881 018-26921 014-26901 -
50 μL 013-26873 010-26883 014-26923 010-26903 012-27781
Clone No. BAN50 BNT77 BA27 BC05 2C8
Host/Sub-class Mouse/IgG1・κ Mouse/IgA・κ Mouse/IgG2a・κ Mouse/IgG1・κ Mouse/IgG2b
Application* WB, IP, IHC, ICC, ELISA IP, IHC, ELISA WB, IHC, ELISA WB, IHC, ELISA WB, IHC
Antibody concentration 0.9-1.3 mg/mL 0.9-1.3 mg/mL 0.9-1.3 mg/mL 0.9-1.3 mg/mL 1.0 mg/mL
Aβ-Reactivity Human Aβ40 + + + - +
Aβ42 + + - + +
Aβ43 + + - + +
Mouse/Rat Aβ40 - + + - +
Aβ42 - + - + +
Aβ43 - + - + +

*Application
WB=Western Blot, IP=Immunoprecipitation, IHC=Immunohistochemistry, ICC=Immunocytochemistry

Aβ antibody

Human Aβ specific antibody
Wako Cat. No. Product Name Grade Package size
017-26871 Anti Human Amyloid β, Monoclonal Antibody (BAN50) for immunochemistry 10 μL
013-26873 50 μL
Antibody Information
Antigen Amyloid β Application* WB, IP, IHC,
ICC, ELISA
Isotype IgG1・κ

■Immunostaining image
Brain of Alzheimer's model mouse

01222_img02.jpg


The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., Graduate School of Medicine, University of Tokyo in Japan.

Antigen
information
Human Amyloid β 1-16 a.a. Species cross reactivity Human Label Unlabeled
Antigen
synonyms
- Host Mouse Clone No. BAN50
Summary Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with N-terminal of human Aβ. The antibody was developed by Takeda Pharmaceutical Company Limited.
References
  1. Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995).
  2. Fukumoto, H., et. al. : J. Neurosci., 30(33), 11157 (2010).
  3. Iwata, H., et. al. : J. Biol. Chem., 276(24), 21678 (2001).
Aβ specific antibody
Wako Cat. No. Product Name Grade Package size
014-26881 Anti Amyloid β, Monoclonal Antibody (BNT77) for immunochemistry 10 μL
010-26883 50 μL
Antibody Information
Antigen Amyloid β Application* IHC,
IP, ELISA
Isotype IgA・κ

■Immunostaining image
Brain of Alzheimer's model mouse

01222_img03.jpg

The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., Graduate School of Medicine, University of Tokyo in Japan.

Antigen
information
Human Amyloid β 11-28 a.a. Species cross reactivity Human, Mouse, Rat Label Unlabeled
Antigen
synonyms
- Host Mouse Clone No. BNT77
Summary Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with middle of Aβ. The antibody was developed by Takeda Pharmaceutical Company Limited.
References
  1. Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995).
  2. Tomita, T., et. al. : J. Neurosci., 19(24), 10627 (1999).
  3. Sudoh, S., et. al. : J. Neurochem., 71(4), 1535 (1998).
Aβ 40 specific antibody
Wako Cat. No. Product Name Grade Package size
018-26921 Anti Amyloid β 40, Monoclonal Antibody (BA27) for immunochemistry 10 μL
014-26923 50 μL
Antibody Information
Antigen Amyloid β40 Application* WB, IHC, ELISA Isotype IgG2a・κ

■Immunostaining image
Brain of Alzheimer's model mouse

01222_img04.jpg

The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., GraduateSchool of Medicine, University of Tokyo in Japan.

Antigen
information
Human Amyloid β 1-40a.a. Species cross reactivity Human, Mouse, Rat Label Unlabeled
Antigen
synonyms
- Host Mouse Clone No. BA27
Summary Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with Aβ40. The antibody was developed by Takeda Pharmaceutical Company Limited.
References
  1. Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995).
  2. Tomita, T., et. al. : J. Neurosci., 19(24), 10627 (1999).
  3. Iwatsubo, T. et al. : Am. J. Pathol., 149(6), 1823 (1996).
  4. Nonomura, A. et al. : J. Neuropathol. Exp. Neurol., 59(11), 1011 (2000).
Aβ42 specific antibody
Wako Cat. No. Product Name Grade Package size
014-26901 Anti Amyloid β42 (43), Monoclonal Antibody (BC05) for immunochemistry 10 μL
010-26903 50 μL
Antibody Information
Antigen Amyloid β42,43 Application* WB, IHC, ELISA Isotype IgG1・κ

■Immunostaining image
Brain of Alzheimer's model mouse

01222_img05.jpg

The data was provided by Kokawa, A., Hashimoto, T., and Iwatsubo, T., Graduate School of Medicine, University of Tokyo in Japan.

Antigen
information
Human Amyloid β 35-43a.a. Species cross reactivity Human, Mouse, Rat Label Unlabeled
Antigen
synonyms
- Host Mouse Clone No. BC05
Summary Amyloid β (Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer's disease, because it is a major component of senile plaques formed in brains of Alzheimer's disease patients. This item is a mouse monoclonal antibody that reacts with Aβ 42 and Aβ 43. The antibody was developed by Takeda Pharmaceutical Company Limited.
References
  1. Asami-Odaka, A., et. al. : Biochemistry, 34(32), 10272 (1995).
  2. Tomita, T., et. al. : J. Neurosci., 19(24), 10627 (1999).
  3. Iwatsubo, T. et al. : Am. J. Pathol., 149(6), 1823 (1996).
  4. Nonomura, A. et al. : J. Neuropathol. Exp. Neurol., 59(11), 1011 (2000).
Aβ specific antibody
Wako Cat. No. Product Name Grade Package size
012-27781 Anti Amyloidβ, Monoclonal Antibody(2C8) for immunochemistry 50 μL
Antibody Information
Antigen Amyloid β Application* WB, IHC Isotype IgG2b

■Immunostaining image
Alzheimer's model mouse
(Red: Aβ)

01222_img06.jpg
Antigen
information
1-16 a.a of human Amyloid β Species cross reactivity Human, Mouse Label Unlabeled
Antigen
synonyms
- Host Mouse Clone No. 2C8
Summary Amyloid β(Aβ) is a peptide which consists of about 40 amino acids. Aβ is considered the cause of Alzheimer’s disease, because it is a major component of senile plaques formed in brains of Alzheimer’s disease patients. This antibody can be used not only in conventional immunostaining and western blot, but also in tissue clearing technique, SCALEVIEW-S.
References
  1. Liu, Y., et. al. : J. Lipid Res., 45, 2368 (2004).
  2. Vehmas, A., et. al. : J. Neuroimmunol., 157(1-2), 99 (2004).

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Amyloid β(Aβ) antibody

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