Interleukin-4(IL4), Human, recombinant, Animal-derived-free

This is a cytokine manufactured without using animal materials in the culture and purification processes.
A cytokine with a diverse range of functions, interleukin 4 (IL-4) is produced primarily by T cells, NK-T cells, basophils and mast cells.
IL-4 promotes the differentiation of naive CD4+T cells to TH2 cells via the expression of GATA-3. This in turn induces the secretion of cytokines associated with the humoral immune response such as IL-4, IL-5, IL-6, IL-10 and IL-13. Another important function is its role in facilitating immunoglobulin class switching of IgM into IgG1 and IgE. Excessive secretion of IL-4 from Th2 cells results in upregulation of IgE production and allergic reactions. The expression and modification of IL-4, GATA-3 and other related molecules is anticipated to be a key factor in developing new methods of preventing and treating allergies and autoimmune disorders.
Solubility: Soluble in water
Source: E. coli, expressed human interleukin-4
Appearance: Lyophilized
Bacterial endotoxins: less than 0.1 ng/μg
Note: It may be hard to recognize the content in the vial due to the slight amount. Centrifuge the vial prior to opening.