Wako Blog

Introducing a wide range of research topics, technical reports, and tips for your experiments.

Chiral Amino Acid Analysis Using LC/MS

This article was written by Sachise Karakawa, Research Institute for Bioscience Products & Fine Chemicals, Ajinomoto Co., Inc., for Vol. 92, No. 1 (January 2023) of Wako Junyaku Jiho.

Amino acids are the building blocks of proteins, and have various physiological functions related to neurotransmission, immunity, etc. Apart from glycine, amino acids have optical isomers (isomers wit...

Analytical Chemistry

The Story of the Development of CTX-ELISA 1B

The original article was written by Masahiro Hirama, Professor Emeritus of Tohoku University, and Acroscale Ltd. (Glytech, Inc.) for Vol. 07 (December 2018) of ChemGrowing.
This article has been translated from the above Japanese version by Fujifilm Wako.

Scientific research, chemistry in particular, originates from "curiosity and ambition" to "create or discover" "something interesting," and makes great progress when "time, advantage of position, and ...

Analytical Chemistry

Risk Assessment and Control in the Guideline for Elemental Impurities in Drugs

The original article by Rina Nishioka, Soichiro Hanakawa of the Sumika Chemical Analysis Service, Ltd., appeared in an e-newsletter of FUJIFILM Wako Pure Chemical Corporation and was translated by the company.

A regulatory guideline for elemental impurities in drug products was formulated by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). In Jap...

Analytical Chemistry

Effects of Trace Metals (Impurities) in Chemicals Used in Semiconductor Manufacture and Their Analysis

The original article by Yukihisa Kawada of the FUJIFILM Corporation, appeared in an e-newsletter of FUJIFILM Wako Pure Chemical Corporation and was translated by the company.

In recent years, the manufacturing process for semiconductors has become increasingly complex in order to meet the technical requirements for smaller size and higher performance. In this situation, qu...

Analytical Chemistry

Arsenic compounds contained in various foods

Arsenic (As) is an element occurring in the Earth's crust mainly as sulfides such as As3S3, As4S4, and FeAsS. Because it is released into the environment through natural phenomena such as volcanic act...

Life Science

Future of BDNF research

This article was written by Dr. Hisatsugu Koshimizu, Research Promotion Headquarters, Fujita Health University.

This series of articles has outlined the role of brain-derived neurotrophic factor (BDNF) in the normal development and function of the central nervous system (CNS) and its possible involvement in the...

Analytical Chemistry

Precautions in Pre-treatment of Environmental Water Samples by Chelating Resin Preconcentration Method

The original article by Dr. Eiji Fujimori of the National Environmental Research and Training Institute, Ministry of the Environment, appeared in an e-newsletter of FUJIFILM Wako and was translated by the company.

Inductively coupled plasma mass spectrometry (ICP-MS) is capable of simultaneous analysis of multiple elements at extremely low levels and is the most sensitive elemental analysis method among common ...

Life Science

Another face of BDNF

This article was written by Naoki Adachi, Department of Physiology, School of Medicine, Showa University.

BDNF/TrkB signaling pathways play beneficial functions in the normal development of neural circuits and regulation of neurotransmission. Therefore, disruption of BDNF/TrkB signaling is a cause of dise...

Life Science

Regulation of Plasticity through the BDNF Pathway and its Role in Psychiatric Disorders

This article was written by Juzoh Umemori, PhD, Docent, A.I. Virtanen Institute, University of Eastern Finland.

The Brain-derived neurotrophic factor (BDNF) regulates neural plasticity, such as neuronal survival and differentiation, by acting on its receptor Neurotrophic receptor tyrosine kinase 2 (Ntrk2, TrkB)...

Life Science

Role of BDNF during development and its relation to neurodevelopmental disorders

This article was written by Dr. Shingo Suzuki, Department of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University.

Brain-derived neurotrophic factor (BDNF) is a trophic factor released mainly from neurons in a neural activity-dependent manner. It is involved in memory and learning by inducing synaptic organization...

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