Nucleic Acid Chemistry

Nucleic acid is the collective term for deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). Nucleic acid synthesis is important in the field of nucleic acid medicines that are attracting attention as alternatives for small molecule drugs. Since the backbone structure of a nucleic acid drug is mainly composed of oligonucleotides and the drug directly acts on the body without gene expression, they are expected to be applicable to patients who have been difficult to treat. In the nucleic acid synthesis, oligonucleotides are synthesized by successive reactions. Therefore, it is important for each process to produce a high yield.

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