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  3. Nucleic Acid Chemistry
  4. Cleavage / Deprotection Reagents
  5. Deprotection of 2' protecting group

Deprotection of 2' protecting group

For the purpose of RNA synthesis, the hydroxy group at the 2'-position of the sugar moiety is also protected. A tert-butyldimethylsilyl group (TBDMS group) or triisopropylsilyloxymethyl group (TOM group) is commonly used as the protecting group. Both TBDMS and TOM groups can be deprotected by treatment with fluoride ions such as tetrabutylammonium (TBAF) solution.

Protecting group at 2' position of the sugar moiety

  • 00182_img01.png
    TBDMS group
  • 00182_img02.png
    TOM group

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