Anti Phosphorylated Tau S422, Monoclonal Antibody(AP422)
- for Immunochemistry
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
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50uL
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In stock in Japan |
Document
Product Overview
Tau is a microtubule-associated protein predominantly expressed in the central nervous system and is a major component of the neurofibrillary tangles found in the neurons of patients with Alzheimer's disease. Because the extent of Tau accumulation in the brain correlates with the severity of cognitive impairment, Tau is considered to play a central role in the pathogenesis of Alzheimer's disease. Tau in neurofibrillary tangles is highly phosphorylated, and this phosphorylation is implicated in the pathology of Alzheimer's disease.
“Anti Phosphorylated Tau S422, Monoclonal Antibody(AP422)” is a mouse monoclonal antibody that recognizes human and mouse Tau phosphorylated serine 422. It can be used for immunohistochemistry and Western blotting.
Antibody Information
| Clonality | Monoclonal (Clone No. AP422) |
|---|---|
| Antigen | Synthetic Peptide (CGG+417-427 aa of human Tau phosphorylated serine 422) |
| Host | Mouse |
| Formulation | PBS, 50% Glycerol, 0.02% Sodium azide |
| Conjugate | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Application | Immunohistochemistry 1:250-1,000 Western blotting 1:250-1,000 |
Data
Application Data
Immunohistochemistry
Species: Human (Alzheimer’s disease)
Site: Brain
Antibody concentration: 1:1,000
Data by courtesy of Dr. Hasegawa, Department of Brain and Neurosciences, Tokyo Metropolitan Institute of Medical Science
FAQ
About Antibody
- What is the subclass of this antibody?
- The subclass of this antibody is IgG1・κ.
- What is the concentration of this antibody?
- The specification for protein concentration is 1.0 mg/mL.
Overview / Applications
| Outline | This product is for research use only. Do not administer it to human. Tau is one of the microtubule-associated proteins, which is mainly expressed in neurons of the central nervous system, and controls the stabilization of microtubules. In the brains of Alzheimer's disease patients, it is reported that neurofibrillary tangle accumulated by phosphorylated Tau is formed, and the extent of its appearance correlates with the severity of dementia. Therefore, Tau is being studied for investigating the cause of Alzheimer's disease and developing therapeutic drugs. This product is mouse monoclonal antibody which recognizes phosphorylated Tau at S422. [Antigen] human Tau 417-427 a.a. phosphorylated S422 (CGGIDMVDpSPQLAT) [Antibody subclass] mouse IgG1 kappa [Species cross reactivity] human, mouse [Experimental adaptation] Western blot (1:1,000), immunohistochemical staining (1:1,000) [Reference] 1)Hasegawa, M., et al.: FEBS Lett., 384, 1, 25(1996). 2)Goedert, M., et al.: FEBS Lett., 409, 1, 57(1997). 3)Buee-Scherrer, V., et al.: FEBS Lett., 515, 1, 151(2002). 4)Delobel, P., et al., J. Neurochem., 83, 2, 412(2002). 5)Bellucci, A., et al.: Am. J. Pathol., 165, 5, 1643(2004). 6)Sylvie, L. C., et al.: PNAS, 103, 25, 9673(2006). 7)Schindowski, K., et al.: Am. J. Pathol., 169, 2, 599(2006). 8)Audouard, E., et al.: Am. J. Pathol., 186, 10, 2709(2016). |
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Property
| Appearance | Liquid |
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Manufacturer Information
Alias
- Anti Tau pS422, Mouse Monoclonal Antibody (Clone No. AP422)
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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