Anti Tau Antibodies
Tau is one of a microtubule-associated protein, which is mainly expressed in neurons of the central nervous system and regulates the stability of microtubules. In the brain of Alzheimer's disease, the accumulation of phosphorylated Tau called Neurofibrillary tangles is observed.
From the fact that Tau aggregates in the brain of Alzheimer's disease, there are some studies against Tau as a possible cause of the disease. Tau has over 40 sites of phosphorylation (Fig. 1) and 6 isoforms (Fig. 2). We offer the antibodies specific for some phosphorylation sites and isoforms.
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Figure 1. Tau phosphorylation sites
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Figure 2. Tau isoforms
Tau antibody Selection Guide
Detectable Tau | Clone No. | Application* | Species cross reactivity |
Host/Sub class | Epitope | Antibody concentration | Wako Cat. No. | ||
---|---|---|---|---|---|---|---|---|---|
10 μL | 50 μL | ||||||||
Total Tau | Mouse, Rat, Human | RTM38 | WB, IHC, ICC | Mouse, Rat, Human | Rat/IgG2a・κ | Tau (417-441 a.a.) |
1.0-1.2 mg/mL | 011-26891 | 017-26893 |
Human specific | RTM49 | WB, IHC, ICC | Human | Rat/IgG1・κ | Tau (2-44a.a.) |
1.0-1.2 mg/mL | 019-26951 | 015-26953 | |
Mouse specific | RTM47 | WB, IHC, ICC | Mouse | Rat/IgG2b・κ | - | 1.0-1.2 mg/mL | 016-26961 | 012-26963 | |
Phosphorylated Tau | Tau T181 | 2E2-A6 | WB, IHC | Human | Rat/IgG2b・κ | Tau pT181 | 1.0-1.1 mg/mL | 012-26603 | 016-26601 |
Tau S199 | 5B8-1E2 | WB, IHC | Human | Rat/IgG2a・κ | Tau pS199 | 1.0-1.1 mg/mL | 019-26613 | 013-26611 | |
Tau S262 | TIP1-35 | WB, ICC, ELISA | Human | Rat/IgG1・λ | Tau pS262 | 0.9 mg/mL | 014-27121 | 010-27123 | |
Tau S422 | AP422 | WB, IHC | Human, Mouse | Mouse/IgG1・κ | Tau pS422 | 1.0mg/mL | 016-27681 | 012-27683 | |
Tau isoform | 2N-Tau | 2C2 | WB, IHC | Human | Rat/IgM・κ | Tau (74-103 a.a.) |
1.0mg/mL | 017-27351 | 013-27353 |
3R-Tau | 2A1-1F4 | WB, IP | Human | Rat/IgG2b・λ | Tau (267-274, 306-313a.a.) |
1.0-1.1 mg/mL | 012-26583 | 016-26581 | |
4R-Tau | 3E8-1A6 | WB, IP | Human | Mouse/IgG1・κ | Tau (273-291a.a.) |
1.0-1.1 mg/mL | 019-26593 | 013-26591 |
*Application
WB=Western Blot, IP=Immunoprecipitation, IHC=Immunohistochemistry, ICC=Immunocytochemistry
Total Tau Antibody
Tau specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
011-26891 | Anti Human/Mouse/Rat Tau, Rat Monoclonal Antibody (RTM38) |
for immunochemistry | 10 μL | ||||
017-26893 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | Tau | Application* | WB, IHC, ICC | Isotype | IgG2a・κ |
■Immunohistochemistry
Wild type mouse brain
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|
Antigen information |
Mouse full length Tau 0N4R isoform |
Species cross reactivity | Human, Mouse, Rat | Label | Unlabeled | ||
Antigen synonyms |
MAPT, Microtubule-Associated Protein Tau |
Host | Rat | Clone No. | RTM38 | ||
Summary | Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes human, mouse and rat Tau. | ||||||
Reference |
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Human Tau specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
019-26951 | Anti Human Tau, Rat Monoclonal Antibody (RTM49) | for immunochemistry | 10 μL | ||||
015-26953 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | Tau | Application* | WB, IHC, ICC | Isotype | IgG1・κ |
■Immunohistochemistry
Wild type mouse brain
|
|
Antigen information |
Human full length Tau 0N4R isoform |
Species cross reactivity | Human | Label | Unlabeled | ||
Antigen synonyms |
MAPT, Microtubule-Associated Protein Tau |
Host | Rat | Clone No. | RTM49 | ||
Summary | Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes human Tau. | ||||||
Reference |
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Mouse Tau specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
016-26961 | Anti Mouse Tau, Rat Monoclonal Antibody (RTM47) | for immunochemistry | 10 μL | ||||
012-26963 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | Tau | Application* | WB, IHC, ICC | Isotype | IgG2b・κ |
■Immunohistochemistry
Wild type mouse brain
|
|
Antigen information |
Mouse Tau full length | Species cross reactivity | Mouse | Label | Unlabeled | ||
Antigen synonyms |
MAPT, Microtubule-Associated Protein Tau |
Host | Rat | Clone No. | RTM47 | ||
Summary | Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes mouse Tau. | ||||||
Reference |
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Phosphorylated Tau Antibody
Phosphorylated Tau (T181) specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
012-26603 | Anti Phosphorylated Tau T181, Rat Monoclonal Antibody (2E2-A6) |
for immunochemistry | 10 μL | ||||
016-26601 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | Tau T181 | Application* | WB, IHC | Isotype | IgG2b・κ |
■Immunostaining image
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|
Antigen information |
171-191 a.a of Human Tau with pT181. |
Species cross reactivity | Human | Label | Unlabeled | ||
Antigen synonyms |
- | Host | Rat | Clone No. | 2E2-A6 | ||
Summary | Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated threonine at position 181 (pT181). | ||||||
Reference | - |
Phosphorylated Tau (S199) specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
019-26613 | Anti Phosphorylated Tau S199, Rat Monoclonal Antibody (5B8-1E2) |
for immunochemistry | 10 μL | ||||
013-26611 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | Tau pT199 | Application* | WB, IHC | Isotype | IgG2a・κ |
■Immunostaining image
|
|
Antigen information |
189-209 a.a of human Tau with pS199. |
Species cross reactivity | Human | Label | Unlabeled | ||
Antigen synonyms |
- | Host | Rat | Clone No. | 5B8-1E2 | ||
Summary | TTau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 199 (pS199). |
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Reference | - |
Phosphorylated Tau (S262) specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
014-27121 | Anti Phosphorylated Tau S262, Rat Monoclonal Antibody (TIP1-35) |
for immunochemistry | 10 μL | ||||
010-27123 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | Tau pS262 | Application* | WB, ICC, ELISA | Isotype | IgG1 |
- |
|
Antigen information |
- | Species cross reactivity | Human, monkey | Label | Unlabeled | ||
Antigen synonyms |
- | Host | Rat | Clone No. | TIP1-35 | ||
Summary | Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 262 (pS262). | ||||||
Reference | - |
Phosphorylated Tau (S422) specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
016-27681 | Anti Phosphorylated Tau S422, Monoclonal Antibody (AP422) |
for immunochemistry | 10 μL | ||||
012-27683 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | Tau pS422 | Application* | WB, IHC | Isotype | IgG1・κ |
■Immunostaining image
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|
Antigen information |
CGG+417-427a.a. of human tau with pS422 |
Species cross reactivity | Human, Mouse | Label | Unlabeled | ||
Antigen synonyms |
- | Host | Mouse | Clone No. | AP422 | ||
Summary | Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 422 (pS422). | ||||||
References |
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Tau Isoform Antibody
2N-Tau specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
017-27351 | Anti 2N-Tau, Rat Monoclonal Antibody (2C2) | for immunochemistry | 10 μL | ||||
013-27353 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | 2N-Tau | Application* | WB, IHC | Isotype | IgM・κ |
■Immunohistchemistry
Alzheimer's disease patient's brain section
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|
Antigen information |
Human Tau full length | Species cross reactivity | Human | Label | Unlabeled | ||
Antigen synonyms |
- | Host | Rat | Clone No. | 2C2 | ||
Summary | TTau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau has 6 isoforms: 2N4R (Tau-441) , 2N3R (Tau-410) , 1N4R (Tau-412) , 1N3R (Tau-381) , 0N4R (Tau-383) , and 0N3R (Tau-352). This product is an antibody that specifically recognizes 2N4R and 2N3R Tau isoforms. | ||||||
Reference | - |
3-Repeat Tau (3R-Tau) specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
012-26583 | Anti 3R-Tau, Rat Monoclonal Antibody (2A1-1F4) | for immunochemistry | 10 μL | ||||
016-26581 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | 3R-Tau | Application* | WB, IP | Isotype | IgG2b・λ |
■WB image
|
|
Antigen information |
Human Tau 267-274, 306-313a.a |
Species cross reactivity | Human | Label | Unlabeled | ||
Antigen synonyms |
- | Host | Rat | Clone No. | 2A1-1F4 | ||
Summary | TauTau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau is classified into 3R-Tau and 4R-Tau which has 3 and 4 microtubules associated domains, respectively, This product is an antibody that specifically recognizes 3R-Tau.。 | ||||||
Reference | - |
4 Repeat Tau (4R-Tau) specific antibody | |||||||
Wako Cat. No. | Product Name | Grade | Package size | ||||
---|---|---|---|---|---|---|---|
019-26593 | Anti 4R-Tau, Monoclonal Antibody (3E8-1A6) | for immunochemistry | 10 μL | ||||
013-26591 | 50 μL | ||||||
Antibody Information | |||||||
Antigen | 4R-Tau | Application* | WB, IP | Isotype | IgG1・κ |
■WB image
|
|
Antigen information |
Human Tau 273-291a.a. |
Species cross reactivity | Human | Label | Unlabeled | ||
Antigen synonyms |
- | Host | Mouse | Clone No. | 3E8-1A6 | ||
Summary | Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau is classified into 3R-Tau and 4R-Tau which has 3 and 4 microtubules associated domains, respectively, This product is an antibody that specifically recognizes 4R-Tau. | ||||||
Reference | - |
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Total Tau Antibodies
Phosphorylated Tau Antibodies
Tau Isoform Antibodies
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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