Anti Tau Antibodies

Tau is one of a microtubule-associated protein, which is mainly expressed in neurons of the central nervous system and regulates the stability of microtubules. In the brain of Alzheimer's disease, the accumulation of phosphorylated Tau called Neurofibrillary tangles is observed.
From the fact that Tau aggregates in the brain of Alzheimer's disease, there are some studies against Tau as a possible cause of the disease. Tau has over 40 sites of phosphorylation (Fig. 1) and 6 isoforms (Fig. 2). We offer the antibodies specific for some phosphorylation sites and isoforms.

  • Figure 1. Tau phosphorylation sites
    01222_img06.png




      01222_img07.png
  • Figure 2. Tau isoforms
    01222_img08.png

Tau antibody Selection Guide

Detectable Tau Clone No. Application* Species cross
reactivity
Host/Sub class Epitope Antibody concentration Wako Cat. No.
10 μL 50 μL
Total Tau Mouse, Rat, Human RTM38 WB, IHC, ICC Mouse, Rat, Human Rat/IgG2a・κ Tau
(417-441 a.a.)
1.0-1.2 mg/mL 011-26891 017-26893
Human specific RTM49 WB, IHC, ICC Human Rat/IgG1・κ Tau
(2-44a.a.)
1.0-1.2 mg/mL 019-26951 015-26953
Mouse specific RTM47 WB, IHC, ICC Mouse Rat/IgG2b・κ - 1.0-1.2 mg/mL 016-26961 012-26963
Phosphorylated Tau Tau T181 2E2-A6 WB, IHC Human Rat/IgG2b・κ Tau pT181 1.0-1.1 mg/mL 012-26603 016-26601
Tau S199 5B8-1E2 WB, IHC Human Rat/IgG2a・κ Tau pS199 1.0-1.1 mg/mL 019-26613 013-26611
Tau S262 TIP1-35 WB, ICC, ELISA Human Rat/IgG1・λ Tau pS262 0.9 mg/mL 014-27121 010-27123
Tau S422 AP422 WB, IHC Human, Mouse Mouse/IgG1・κ Tau pS422 1.0mg/mL 016-27681 012-27683
Tau isoform 2N-Tau 2C2 WB, IHC Human Rat/IgM・κ Tau
(74-103 a.a.)
1.0mg/mL 017-27351 013-27353
3R-Tau 2A1-1F4 WB, IP Human Rat/IgG2b・λ Tau
(267-274, 306-313a.a.)
1.0-1.1 mg/mL 012-26583 016-26581
4R-Tau 3E8-1A6 WB, IP Human Mouse/IgG1・κ Tau
(273-291a.a.)
1.0-1.1 mg/mL 019-26593 013-26591

*Application
WB=Western Blot, IP=Immunoprecipitation, IHC=Immunohistochemistry, ICC=Immunocytochemistry

Total Tau Antibody

Tau specific antibody
Wako Cat. No. Product Name Grade Package size
011-26891 Anti Human/Mouse/Rat Tau, Rat Monoclonal Antibody
(RTM38)
for immunochemistry 10 μL
017-26893 50 μL
Antibody Information
Antigen Tau Application* WB, IHC, ICC Isotype IgG2a・κ
■Immunohistochemistry
Wild type mouse brain

01222_img18.png


The data was provided by Miyasaka, T., Doshisha University in Japan

Antigen
information
Mouse full length
Tau 0N4R isoform
Species cross reactivity Human, Mouse, Rat Label Unlabeled
Antigen
synonyms
MAPT, Microtubule-Associated
Protein Tau
Host Rat Clone No. RTM38
Summary Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes human, mouse and rat Tau.
Reference
  1. Kubo, A., et al. : J. Comp. Neurol., 527(5), 985 (2018).
Human Tau specific antibody
Wako Cat. No. Product Name Grade Package size
019-26951 Anti Human Tau, Rat Monoclonal Antibody (RTM49) for immunochemistry 10 μL
015-26953 50 μL
Antibody Information
Antigen Tau Application* WB, IHC, ICC Isotype IgG1・κ
■Immunohistochemistry
Wild type mouse brain

01222_img19.png


The data was provided by Miyasaka, T., Doshisha University in Japan

Antigen
information
Human full length
Tau 0N4R isoform
Species cross reactivity Human Label Unlabeled
Antigen
synonyms
MAPT, Microtubule-Associated
Protein Tau
Host Rat Clone No. RTM49
Summary Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes human Tau.
Reference
  1. Kubo, A., et al. : J. Comp. Neurol., 527(5), 985 (2018).
Mouse Tau specific antibody
Wako Cat. No. Product Name Grade Package size
016-26961 Anti Mouse Tau, Rat Monoclonal Antibody (RTM47) for immunochemistry 10 μL
012-26963 50 μL
Antibody Information
Antigen Tau Application* WB, IHC, ICC Isotype IgG2b・κ
■Immunohistochemistry
Wild type mouse brain

01222_img20.png


The data was provided by Miyasaka, T., Doshisha University in Japan

Antigen
information
Mouse Tau full length Species cross reactivity Mouse Label Unlabeled
Antigen
synonyms
MAPT, Microtubule-Associated
Protein Tau
Host Rat Clone No. RTM47
Summary Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is a rat monoclonal antibody that specifically recognizes mouse Tau.
Reference
  1. Kubo, A., et al. : J. Comp. Neurol., 527(5), 985 (2018).

Phosphorylated Tau Antibody

Phosphorylated Tau (T181) specific antibody
Wako Cat. No. Product Name Grade Package size
012-26603 Anti Phosphorylated Tau T181, Rat Monoclonal Antibody
(2E2-A6)
for immunochemistry 10 μL
016-26601 50 μL
Antibody Information
Antigen Tau T181 Application* WB, IHC Isotype IgG2b・κ

■Immunostaining image
Brain of Alzheimer's disease patient

01222_img12.jpg


The data was provided by
Miyasaka, T., Doshisha University in Japan.

Antigen
information
171-191 a.a of Human Tau
with pT181.
Species cross reactivity Human Label Unlabeled
Antigen
synonyms
- Host Rat Clone No. 2E2-A6
Summary Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated threonine at position 181 (pT181).
Reference -
Phosphorylated Tau (S199) specific antibody
Wako Cat. No. Product Name Grade Package size
019-26613 Anti Phosphorylated Tau S199, Rat Monoclonal Antibody
(5B8-1E2)
for immunochemistry 10 μL
013-26611 50 μL
Antibody Information
Antigen Tau pT199 Application* WB, IHC Isotype IgG2a・κ

■Immunostaining image
Brain of Alzheimer's disease patient

01222_img13.jpg


The data was provided by
Miyasaka, T., Doshisha University in Japan

Antigen
information
189-209 a.a of human Tau
with pS199.
Species cross reactivity Human Label Unlabeled
Antigen
synonyms
- Host Rat Clone No. 5B8-1E2
Summary TTau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that
specifically recognizes Tau with phosphorylated serine at position 199 (pS199).
Reference -
Phosphorylated Tau (S262) specific antibody
Wako Cat. No. Product Name Grade Package size
014-27121 Anti Phosphorylated Tau S262, Rat Monoclonal Antibody
(TIP1-35)
for immunochemistry 10 μL
010-27123 50 μL
Antibody Information
Antigen Tau pS262 Application* WB, ICC, ELISA Isotype IgG1

-

Antigen
information
- Species cross reactivity Human, monkey Label Unlabeled
Antigen
synonyms
- Host Rat Clone No. TIP1-35
Summary Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 262 (pS262).
Reference -
Phosphorylated Tau (S422) specific antibody
Wako Cat. No. Product Name Grade Package size
016-27681 Anti Phosphorylated Tau S422, Monoclonal Antibody
(AP422)
for immunochemistry 10 μL
012-27683 50 μL
Antibody Information
Antigen Tau pS422 Application* WB, IHC Isotype IgG1・κ

■Immunostaining image
Brain of Alzheimer's disease patient

01222_img14.jpg


The data was provided by Dr, Hasegawa, M., Tokyo Metropolitan Institute of Medical Science in Japan.

Antigen
information
CGG+417-427a.a. of human
tau with pS422
Species cross reactivity Human, Mouse Label Unlabeled
Antigen
synonyms
- Host Mouse Clone No. AP422
Summary Tau is a microtubule-associated protein, mainly expressed in neurons in central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. This product is an antibody that specifically recognizes Tau with phosphorylated serine at position 422 (pS422).
References
  1. Hasegawa, M., et al. : FEBS Lett., 384(1), 25 (1996).
  2. Goedert, M., et al. : FEBS Lett., 409(1), 57 (1997).
  3. Buée-Scherrer, V., et al. : FEBS Lett., 515(1), 151 (2002).
  4. Delobel, P., et al.: J. Neurochem., 83(2), 412 (2002).
  5. Bellucci, A., et al. : Am. J. Pathol., 165(5), 1643 (2004).
  6. Sylvie, L. C., et al. : PNAS, 103(25), 9673 (2006).
  7. Schindowski, K., et al. : Am. J. Pathol., 169(2), 599 (2006).
  8. Audouard, E., et al. : Am. J. Pathol., 186(10), 2709 (2016).

Tau Isoform Antibody

2N-Tau specific antibody
Wako Cat. No. Product Name Grade Package size
017-27351 Anti 2N-Tau, Rat Monoclonal Antibody (2C2) for immunochemistry 10 μL
013-27353 50 μL
Antibody Information
Antigen 2N-Tau Application* WB, IHC Isotype IgM・κ
■Immunohistchemistry
Alzheimer's disease patient's brain section

01222_img21.jpg


The data was provided by Miyasaka, T., Doshisha University in Japan

Antigen
information
Human Tau full length Species cross reactivity Human Label Unlabeled
Antigen
synonyms
- Host Rat Clone No. 2C2
Summary TTau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau has 6 isoforms: 2N4R (Tau-441) , 2N3R (Tau-410) , 1N4R (Tau-412) , 1N3R (Tau-381) , 0N4R (Tau-383) , and 0N3R (Tau-352). This product is an antibody that specifically recognizes 2N4R and 2N3R Tau isoforms.
Reference -
3-Repeat Tau (3R-Tau) specific antibody
Wako Cat. No. Product Name Grade Package size
012-26583 Anti 3R-Tau, Rat Monoclonal Antibody (2A1-1F4) for immunochemistry 10 μL
016-26581 50 μL
Antibody Information
Antigen 3R-Tau Application* WB, IP Isotype IgG2b・λ

■WB image
Human tau recombinant mixtures
(2N4R, 2N3R, 1N4R, 1N3R, 0N4R,
0N3R-Tau)

01222_img16.jpg


The data was provided by Miyasaka, T., Doshisha
University in Japan.

Antigen
information
Human Tau
267-274, 306-313a.a
Species cross reactivity Human Label Unlabeled
Antigen
synonyms
- Host Rat Clone No. 2A1-1F4
Summary TauTau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau is classified into 3R-Tau and 4R-Tau which has 3 and 4 microtubules associated domains, respectively, This product is an antibody that specifically recognizes 3R-Tau.。
Reference -
4 Repeat Tau (4R-Tau) specific antibody
Wako Cat. No. Product Name Grade Package size
019-26593 Anti 4R-Tau, Monoclonal Antibody (3E8-1A6) for immunochemistry 10 μL
013-26591 50 μL
Antibody Information
Antigen 4R-Tau Application* WB, IP Isotype IgG1・κ

■WB image
Human tau recombinant mixtures
(2N4R, 2N3R, 1N4R, 1N3R, 0N4R,
0N3R-Tau)

01222_img17.jpg


The data was provided Miyasaka, T., Doshisha
University in Japan.

Antigen
information
Human Tau
273-291a.a.
Species cross reactivity Human Label Unlabeled
Antigen
synonyms
- Host Mouse Clone No. 3E8-1A6
Summary Tau is a microtubule-associated protein, mainly expressed in neurons in the central nervous system, and regulates stabilization of microtubules. In the brain of Alzheimer's disease patients, neurofibrillary tangles are formed which are composed of accumulated phosphorylated forms of Tau. The degree of these tangles correlates to the severity of dementia. Based on this finding, Tau has been investigated to find out the etiology and to discover drugs for Alzheimer's disease. Tau is classified into 3R-Tau and 4R-Tau which has 3 and 4 microtubules associated domains, respectively, This product is an antibody that specifically recognizes 4R-Tau.
Reference -

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Total Tau Antibodies

Phosphorylated Tau Antibodies

Tau Isoform Antibodies

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