Amino Acid Standard
Amino acids are organic compounds that constitute proteins, one of the energy-producing nutrients. The amino acid concentrations in the blood (plasma) are precisely controlled, and fluctuations in amino acids in biological fluids are used as indicators of body metabolism and disease. With the progress in the development of technology to screen the possibility of disease in the future, it is required to measure amino acids in blood samples and quantify amino acids more accurately.
FUJIFILM Wako was qualified for the first time in Japan as a "Amino acid mixture standard material producer" on the basis of the accreditation system of the National Institute of Technology and Evaluation (ASNITE), and we sell first in Japan the Amino Acid Standard of the certified reference materials (CRM) with warranted metrological traceability*1. Amino Acids Mixture Standard Solutions (High Range) are prepared with the highly accurate liquid preparation technology cultivated in the development of the CRM amino acid standards. And raw materials are "internally certified products with assured amino acid as an impurity" or "reference material with assured traceability (TRM: Traceable Reference Material)". Therefore, you can use a standard solution with more accurate concentration than before.
*1: What is "metrological traceability"?
It is property of a measurement result whereby the result can be related to a reference through a documented unbroken chain of calibrations.
Features
- Amino Acids Mixture Standard Solution at high concentration*2
- Preparation with high precision liquid preparation technology cultivated in the development of certified reference materials
- Use "internally certified products with assured amino acid as an impurity" or "reference material with assured traceability" as raw materials
*2: 2-Aminoadipic acid is not contained.
Composition / Abbreviation
Composition
| Type | P-Ser | Tau | PEA | Urea | Asp | Hyp | Thr | Ser | Asn | Glu | Gln | Sar | Aad | Pro | Gly | Ala | Clt | Abu | Val | (Cys)2 | Met | Hcy(Ala) | Ile | Leu | Tyr |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AN | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |||
| B | |||||||||||||||||||||||||
| H | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Type | Phe | bAla | bAlb | 4Abu | Trp | MEA | NH4 | 5Hyl | Orn | Lys | 1Mehis | His | 3Mehis | Ans | Car | Arg |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AN | ✓ | ✓ | ✓ | |||||||||||||
| B | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ||||
| H | ✓ | ✓ | ✓ | ✓ | ✓ |
AN: Amino Acids Mixture Standard Solution, Type AN (Code No. 016-28161, 010-28164)
B: Amino Acids Mixture Standard Solution, Type B (Code No. 012-28141, 016-28144)
H: Amino Acids Mixture Standard Solution, Type H (Code No. 019-28151, 013-28154)
Abbreviation
| Abbreviation | Amino acids | Abbreviation | Amino acids | Abbreviation | Amino acids |
|---|---|---|---|---|---|
| P-Ser | O-Phosphoserine | Ala | Alanine | MEA | 2-Aminoethanol |
| Tau | Taurine | Cit | Citrulline | NH4 | Ammonium Ion |
| PEA | O-Phosphoethanolamine | Abu | 2-Aminobutyric Acid | 5Hyl | 5-Hydroxylysine |
| Urea | Urea | Val | Valine | Orn | Ornithine |
| Asp | Aspartic Acid | (Cys)2 | Cystine | Lys | Lysine |
| Hyp | Hydroxyproline | Met | Methionine | 1Mehis | 1-Methylhistidine |
| Thr | Threonine | Hcy(Ala) | Cystathionine | His | Histidine |
| Ser | Serine | Ile | Isoleucine | 3Mehis | 3-Methylhistidine |
| Asn | Asparagine | Leu | Leucine | Ans | Anserine |
| Glu | Glutamic Acid | Tyr | Tyrosine | Car | Carnosine |
| Gln | Glutamine | Phe | Phenylalanine | Arg | Arginine |
| Sar | Sarcosine | bAla | β-Alanine | ||
| Aad | 2-Aminoadipic Acid | bAib | 3-Aminoisobutyric Acid | ||
| Pro | Proline | 4Abu | 4-Aminobutyric Acid | ||
| Gly | Glycine | Trp | Tryptophan | ||
Concentration Information
Type AN
| Components | Concentration (μmol/mL) |
Components | Concentration (μmol/mL) |
Components | Concentration (μmol/mL) |
|---|---|---|---|---|---|
| O-Phospho-L-serine | 1.19-1.31 | Sarcosine | 5.94-6.56 | L-Isoleucine | 2.38-2.62 |
| Taurine | 1.19-1.31 | Glycine | 2.38-2.62 | L-Leucine | 2.38-2.62 |
| O-Phosphoethanolamine | 1.19-1.31 | L-Alanine | 2.38-2.62 | L-Tyrosine | 2.38-2.62 |
| Urea | 47.5-52.5 | L-Citrulline | 2.38-2.62 | L-Phenylalanine | 2.38-2.62 |
| L-Aspartic Acid | 2.38-2.62 | DL-2-Aminobutyric Acid | 1.19-1.31 | β-Alanine | 2.38-2.62 |
| L-Hydroxyproline | 2.38-2.62 | L-Valine | 2.38-2.62 | DL-3-Aminoisobutyric Acid | 2.38-2.62 |
| L-Threonine | 2.38-2.62 | L-Cystine | 2.38-2.62 | L-Hydroxyproline | 2.38-2.62 |
| L-Serine | 2.38-2.62 | L-Methionine | 2.38-2.62 | L-Proline | 2.38-2.62 |
| L-Glutamic Acid | 2.38-2.62 | L-Cystathionine | 1.19-1.31 | Cl Ion (Reference value) | 0.10-0.13 |
Type B
| Components | Concentration (μmol/mL) |
Components | Concentration (μmol/mL) |
|---|---|---|---|
| 4-Aminobutyric Acid | 2.38-2.62 | 1-Methyl-L-histidine | 2.38-2.62 |
| 2-Aminoethanol | 2.38-2.62 | L-Histidine | 2.38-2.62 |
| Ammonium Chloride | 2.38-2.62 | 3-Methyl-L-histidine | 2.38-2.62 |
| 5-Hydroxy-DL-lysine | 2.38-2.62 | L-Anserine | 2.38-2.62 |
| L-Ornithine | 2.38-2.62 | L-Carnosine | 2.38-2.62 |
| L-Lysine | 2.38-2.62 | L-Arginine | 2.38-2.62 |
| Cl Ion (Reference value) | 0.10-0.13 | ||
Type H
| Components | Concentration (μmol/mL) |
Components | Concentration (μmol/mL) |
|---|---|---|---|
| L-Aspartic Acid | 2.38-2.62 | L-Isoleucine | 2.38-2.62 |
| L-Threonine | 2.38-2.62 | L-Leucine | 2.38-2.62 |
| L-Serine | 2.38-2.62 | L-Tyrosine | 2.38-2.62 |
| L-Glutamic Acid | 2.38-2.62 | L-Phenylalanine | 2.38-2.62 |
| Glycine | 2.38-2.62 | Ammonium Chloride | 2.38-2.62 |
| L-Alanine | 2.38-2.62 | L-Lysine | 2.38-2.62 |
| L-Valine | 2.38-2.62 | L-Histidine | 2.38-2.62 |
| L-Cystine | 2.38-2.62 | L-Arginine | 2.38-2.62 |
| L-Methionine | 2.38-2.62 | L-Proline | 2.38-2.62 |
| Cl Ion (Reference value) | 0.10-0.13 | ||
Concentration Divergence Between Conventional Products and This Product
The concentrations of the Amino Acids Mixture Standard Solution (High Range) and conventional product were determined using the Amino Acids Mixture Standard Solution [CRM], and the differences between the values were evaluated. The results are shown below.
| Conventional product | Type AN-2: 011-14463, 015-14461 | Type B: 012-08643, 016-08641 | Type H: 019-08393, 013-08391 |
|---|---|---|---|
| This product | Type AN: 016-28161, 010-28164 | Type B: 012-28141, 016-28144 | Type H: 019-28151, 013-28154 |
Type AN
| Amino acids | Concentration (μmol/mL) |
Concentration divergence between conventional products and this product |
Amino acids | concentration (μmol/mL) |
Concentration divergence between conventional products and this product |
|---|---|---|---|---|---|
| P-Ser | 1.25 | - | Val | 2.50 | - |
| Tau | 1.25 | - | (Cys)2 | 2.50 | - |
| PEA | 1.25 | max. 5%, min. 2% | Met | 2.50 | - |
| Urea | 50.0 | max. 5%, min. 2% | Hcy(Ala) | 1.25 | - |
| Asp | 2.50 | - | Ile | 2.50 | - |
| Thr | 2.50 | max. 5%, min. 2%% | Leu | 2.50 | - |
| Ser | 2.50 | - | Tyr | 2.50 | - |
| Glu | 2.50 | - | Phe | 2.50 | - |
| Sar | 6.25 | max. 5%, min. 2% | bAla | 2.50 | max. 5%, min. 2% |
| Gly | 2.50 | - | bAib | 2.50 | min. 5% |
| Ala | 2.50 | - | Hyp | 2.50 | max. 5%, min. 2% |
| Cit | 2.50 | - | Pro | 2.50 | - |
| Abu | 1.25 | max. 5%, min. 2% | |||
Type B
| Amino acids | concentration (μmol/mL) |
Concentration divergence between conventional products and this product |
|---|---|---|
| 4Abu | 2.50 | - |
| MEA | 2.50 | - |
| NH4 | 2.50 | - |
| 5Hyl | 2.50 | - |
| Orn | 2.50 | - |
| Lys | 2.50 | - |
| 1Mehis | 2.50 | - |
| His | 2.50 | - |
| 3Mehis | 2.50 | - |
| Ans | 2.50 | max. 5%, min. 2% |
| Car | 2.50 | max. 5%, min. 2% |
| Arg | 2.50 | - |
Type H
| Amino acids | concentration (μmol/mL) |
Concentration divergence between conventional products and this product |
|---|---|---|
| Asp | 2.50 | - |
| Thr | 2.50 | - |
| Ser | 2.50 | - |
| Glu | 2.50 | - |
| Gly | 2.50 | - |
| Ala | 2.50 | - |
| Val | 2.50 | - |
| (Cys)2 | 2.50 | - |
| 3Mehis | 2.50 | - |
| Met | 2.50 | - |
| Ile | 2.50 | - |
| Leu | 2.50 | - |
| Tyr | 2.50 | - |
| Phe | 2.50 | - |
| NH4 | 2.50 | - |
| Lys | 2.50 | - |
| His | 2.50 | - |
| Arg | 2.50 | - |
| Pro | 2.50 | - |
-: No significant difference has been observed.
Product List
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Amino Acids Mixture Standard Solution
Amino Acids Mixture Standard Solution (CRM)
Mixture Internal Standard Solution
Amino Acids Standard Solution
Certified Reference Material by NMIJ (NMIJ CRM)
Traceable Reference Material (TRM)
Standard
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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