VA-044, Azo Initiator
- Wako 1st Grade
- Specification Assay :
- 97.0+% (Gas Analysis)
- Manufacturer :
- FUJIFILM Wako Chemicals U.S.A. Corporation
- Storage Condition :
- Protect from light
- CAS RN® :
- 27776-21-2
- Molecular Formula :
- C12H24Cl2N2
- Molecular Weight :
- 323.27
- GHS :
-
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50 G
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500 G
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Document
Application Data
Tissue-Clearing-CLARITY
CLALITY is the technique develped in the Deisseroth lab at Stanford University.
Chung, K. et al., Nature, 497, 332-337 (2013).
This protocol transforms intact tissues including whole organs into an optically transparent hydrogel-hybridized form, ready for molecular phenotyping and high resolution 3D imaging.
References
- Chung, K., Wallace, J., Kim, S. Y., Kalyanasundaram, S., Andalman, A. S., Davidson, T. J., Mirzabekov, J. J., Zalocusky, K. A., Mattis, J., Denisin, A. K., Pak, S., Bernstein, H., Ramakrishnan, C., Grosenick, L., Gradinaru, V. and Deisseroth, K.: "Structural and molecular interrogation of intact biological systems". Nature, 497, 7449, 332-337 (2013). PMID: 23575631
- Chung K., and Deisseroth. K.: "CLALITY for mapping the nervous system". Nature, 10, 508-513 (2013). PMID: 23722210
- Underwood E.: "Neuroscience. New tools light up the intricacies of the brain". Science, 342, 917-918 (2013). PMID: 24264967
- Tomer, R., Ye, L., Hsueh, B., and Deisseroth, K.: " Adcanced CLARITY for rapid and high-resolution imaging of intact tissues. Nature Protocols, 9, 7, 1682-1697 (2014). PMID: 24945384
- Yang, B., Treweek, J. B., Kulkami, R. P., Deverman, B. E., Chen, C. K., Lubeck, E., Shah, S., Cai, L., and Gradinaru, V.: "Single-cell phenotyping withing transparent intact tissue through whole-body clearing". Cell, 158, 945-958 (2014). PMID: 25088144
- Ye. L., Allen, W. E., Thompson, K. R., Tian, Q., Hsueh, B., Ramakrishnan, C., Wang, A. C., Jennings, J. H., Adhikari, a., Halpern, C. H., Witten, I. B., Barth, A. L., Luo, L., McNab., J. A., and Deisseroth., K.: "Wiring and Molecular Features of Prefrontal Ensembles Representing Distinct Experiences". Cell, 165, 1776-1788 (2016). PMID: 27238022
- Ku., T., Swaney, J., Park, J. Y., Albanese, A., Murray, E., Cho, J. H. Park, Y. G., Mangena, V., Chen, J., and Chung, K.: "Multiplexed and scalable super-resolution imaging of three-dimensional protein localization in size-adjustable tissues". Nature Biotechnol., 34, 973-981 (2016). PMID: 27454740
- Kadoki, M., Patil., A., Thaiss, C. C., Brooks, D. J. Pandey, S., Deep, D., Alvarez, D., von Andrian, U. H., Wagers, A. J., Nakai, K., Mikkelsen, T. S., Soumillon, M., and Chevrier, N. " Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues". Cell, 171, 398-413 (2017). PMID: 28942919
Video from Nature Journal
Watch this video to know more about CLARITY | Nature Video-YouTube
Overview / Applications
| Outline | VA-044 is a non-nitrile, cationic water-soluble azo polymerization initiator. It is highly effective for the polymerization of water-soluble vinyl monomer. The 10-hour half-lifetemperature is as low as 44 ºC, and the product is active at low temperatures. |
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Property
| Appearance | white - light yellow crystals or crystalline powder |
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| Specificity | 10-hour half life temperature: 44 ºC (Water) |
| Solubility | water: free soluble. methanol: sparingly soluble. Ethanol: very slightly soluble. acetone, toluene: insoluble. |
| Melting Point | 188-193 °C |
Manufacturer Information
Alias
- 2,2'-Azobis[2-(2-imidazolin-2-yl)propane] Dihydrochloride
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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