Mycalolide B

for Biochemistry

Specification Assay :: 95.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at -20 degrees C.

CAS RN^® :: 122752-21-0
Molecular Formula :: C52H74N4O17
Molecular Weight :: 1027.16

GHS :

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	Distributor 132-12081 Barcode No 4987481298910	100ug	List Price 352.00 USD	Out of Stock Inquire	Certificate of Analysis

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Application

Overview / Applications

Outline	This product is for research use only. Do not administer it to human. Recent studies have pinpointed Mycalolide B, a marine toxin, as an inhibitor of actin polymerization, yet in a manner which differs from that of Cytochalasin D. Cytochalasin D depolymerized F actin at a slow rate by capping the terminal binding region of F-actin. Mycalolide B, on the other hand, initiates polymerization by actually cleaving F-actin with specificity, binding with it at 1:1 (m/m) ratio and thus restoring it to G-actin. Mycalolide B has been further attributed with a decrease in Mg2+-ATPase activity when examining its effects on actomyosin, or various chicken and rabbit muscular activity. Solubility: Soluble in methanol, isopropanol and DMSO. IC50: 10-50 nM (L1210 Leukemia cells).

Outline

This product is for research use only. Do not administer it to human.

Recent studies have pinpointed Mycalolide B, a marine toxin, as an inhibitor
of actin polymerization, yet in a manner which differs from that of Cytochalasin
D. Cytochalasin D depolymerized F actin at a slow rate by capping the terminal
binding region of F-actin. Mycalolide B, on the other hand, initiates polymerization
by actually cleaving F-actin with specificity, binding with it at 1:1 (m/m)
ratio and thus restoring it to G-actin.

Mycalolide B has been further attributed with a decrease in Mg2+-ATPase
activity when examining its effects on actomyosin, or various chicken and
rabbit muscular activity.

Solubility: Soluble in methanol, isopropanol and DMSO. IC50:
10-50 nM (L1210 Leukemia cells).

Property

Specific Rotation	-53.4℃ (D) (c=1.3 CHCl3)

Manufacturer Information

Alias

Same CAS list

Related Information

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