Anti CD44v8, Monoclonal Antibody (C44Mab-94)
- for Immunochemistry
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
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100ug
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In stock in Japan |
※Check availability in the US with the distributor.
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Product Overview
CD44 is a transmembrane glycoprotein expressed in various cell types, including endothelial cells, epithelial cells, and fibroblasts. It serves as a receptor for hyaluronic acid (HA). The human CD44 gene consists of 19 exons. Alternative splicing gives rise to the smallest standard form of CD44 (CD44s), which consists of 10 constant exons (the first five and the last five), and to CD44 variants (CD44v), which contain combinations of nine variable exons in addition to the constant exons. CD44v8 expresses exon v8. Both CD44s and CD44v are widely used as markers for cancer stem cells and are involved in the regulation of cancer cell behavior through their interactions with hyaluronic acid. In particular, CD44v has been implicated in promoting tumor growth, metastasis, and the activation of intracellular signaling pathways.
This product is a monoclonal antibody against human CD44v8. It is suitable for use in ELISA, flow cytometry, immunohistochemistry, and Western blotting.
Antibody Information
| Clonality | Monoclonal |
|---|---|
| Antigen | CD44v3-10 expressed PANC-1 cells |
| Host | Mouse |
| Formulation | PBS, 0.1% sodium azide |
| Concentration | 1.0 mg/mL |
| Subclass | IgG1·κ |
| Conjugate | Unconjugated |
| Cross-reactivity | Human |
| Application |
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Application Data
Immunohistochemistry
- Animal specie:
- Human
- Sample:
- Gastric cancer (GC)/ Diffuse-type gastric cancer (DGC)/Intestinal-type gastric cancer (IGC)
- Antibody concentration:
- 5 μg/mL
Western blotting
- Cell type:
- CHO cells, HSC cells, MKN cells, NUGC cells
(CHO/CD44s is the forced expression of human CD44s,
CHO/CD44v3-v10 is the forced expression of human CD44v3-v10) - Antibody concentration:
- 10 μg/mL
Note: The data for immunohistochemistry and Western blotting are reproduced from reference 1) under CCBY 4.0.
References
- Suzuki, H. et al.: Antibodies., 12(3), 45(2023).
Development of a Novel Anti-CD44 Variant 8 Monoclonal Antibody C44Mab-94 against Gastric Carcinomas
Overview / Applications
Property
| Concentration | Protein : 1.0mg/mL |
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Manufacturer Information
Alias
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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