Anti Parvalbumin Antibodies

Parvalbumin (PV) is a low-molecular-weight calcium-binding protein, with an approximate molecular weight of 12 kDa, primarily involved in the regulation of intracellular calcium signaling¹⁾. It is expressed in muscles and nerves, including various brain regions such as chandelier cells and basket cells in the cerebral cortex, as well as Purkinje cells in the cerebellum^2-4).

Parvalbumin is recognized as a marker protein for inhibitory GABAergic interneurons. GABAergic interneurons in the neocortex are broadly classified into three types based on marker protein expression: (1) parvalbumin-positive neurons, (2) somatostatin-positive neurons, and (3) 5HT3a receptor-positive neurons⁴⁾. Parvalbumin-positive cells are characterized by their rapid firing and repolarization compared to other neurons, and are involved in regulating neurotransmission, neural plasticity, and the formation and maintenance of oscillations⁵⁾. It is believed that abnormalities in the expression of parvalbumin or parvalbumin-positive neurons may contribute to the development of schizophrenia.

“Anti Parvalbumin, Guinea Pig” is a guinea pig polyclonal antibody that reacts with PV⁶⁾. It can be used to perform multiplex immunohistochemistry.

Antibody Information

Application Data

Immunohistochemistry

Species: Mouse
Site: Sensory cortex
Sample: Frozen section
Antibody concentration: 1:1,500

Data by courtesy of
Dr. Miyata, Department of Applied Biology, Kyoto Institute of Technology

1. Cates, M. S. et al.: Structure, 7(10), 1269(1999).
   Metal-ion affinity and specificity in EF-hand proteins: coordination geometry and domain plasticity in parvalbumin
2. Taniguchi, H., Lu, J. and Huang, Z. J.: Science, 339(6115), 70(2013).
   The spatial and temporal origin of chandelier cells in mouse neocortex
3. Schwaller, B., Meyer, M. and Schiffmann, S.: The cerebellum, 1, 241(2002).
   ‘New’ functions for ‘old’ proteins: The role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice
4. Rudy, B., Fishell, G., Lee, S. and Hjerling‐Leffler, J.: Dev. Neurobiol., 71(1), 45(2011).
   Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
5. Ruden, J. B. et al.: Neuropsychopharmacology, 46(2), 279(2021).
   Parvalbumin interneuron vulnerability and brain disorders
6. Taniguchi, Y. et al.: Cell. Tissue Res., 343, 303(2011).
   Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus