RE44

for Cellbiology

Specification Assay :: 97.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at -20 degrees C.

CAS RN^® :: 1361122-24-8
Molecular Formula :: C28H43NO5
Molecular Weight :: 473.64

Structural Formula
Label
Packing

SDS

Comparison	Product Number	Package Size	Price	Availability	Certificate of Analysis	Purchase
	Distributor 189-03061 Barcode No 4548995028358	1mg	List Price 356.00 USD	Out of Stock Inquire	Certificate of Analysis	Distributor

※Check availability in the US with the distributor.

Document
Application
Overview / Applications
Property
Manufacturer Information
Alias
Same CAS list
Related Information

Document

SDS

Package Insert

Spectral Data

Certificate of Analysis

Calibration Certificate

Analytical Charts

Application

Overview / Applications

Outline	This product is for research use only. Do not administer it to human. In many signal transduction cascades, phosphorylation (protein kinase) and dephosphorylation (protein phosphatase) of proteins are involved in cascade regulation. This product is an inhibitor that specifically inhibits protein phosphatase CDC25B (cell division cycle 25B), a dual specific protein phosphatase targeting phosphorylated serine, threonine, and tyrosine. There are CDC25A, CDC25B, CDC25C isoforms in human. CDC25A and CDC25B have been reported to be overexpressed in various cancer cells such as lung, stomach, and pancreatic cancer. This product is an inhibitor that does not act on CDC25C, but acts selectively on CDC25B and CDC25A. Inhibitory activity : ID50=4.26 umol/L (CDC25B), 13.5 umol/L (CDC25A) [24.9 umol/L (VHR)] 1) Tsuchiya, A. et al., "Dual-specificity phosphatase CDC25A/B inhibitor identified from a focused library with nonelectropholic core structure.", ACS Med. Chem. Lett., 3, 294-298 (2012). 2) Tsuchiya, A. et al., "CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.", Mol. BioSyst., 9, 1026-1034 (2013).

Outline

This product is for research use only. Do not administer it to human.
In many signal transduction cascades, phosphorylation (protein kinase) and dephosphorylation (protein phosphatase) of proteins are involved in cascade regulation. This product is an inhibitor that specifically inhibits protein phosphatase CDC25B (cell division cycle 25B), a dual specific protein phosphatase targeting phosphorylated serine, threonine, and tyrosine.
There are CDC25A, CDC25B, CDC25C isoforms in human. CDC25A and CDC25B have been reported to be overexpressed in various cancer cells such as lung, stomach, and pancreatic cancer. This product is an inhibitor that does not act on CDC25C, but acts selectively on CDC25B and CDC25A.

Inhibitory activity : ID50=4.26 umol/L (CDC25B), 13.5 umol/L (CDC25A)
[24.9 umol/L (VHR)]

1) Tsuchiya, A. et al., "Dual-specificity phosphatase CDC25A/B inhibitor identified from a focused library with nonelectropholic core structure.", ACS Med. Chem. Lett., 3, 294-298 (2012).
2) Tsuchiya, A. et al., "CDC25A-inhibitory RE derivatives bind to pocket adjacent to the catalytic site.", Mol. BioSyst., 9, 1026-1034 (2013).

Property

Appearance	White - slightly brown, crystals - powder or paste

Manufacturer Information

Alias

3-[1-(2-Hydroxybenzylamino)hexadecylidene]-5-(hydroxymethyl)furan(3H,5H)-2,4-dione

Same CAS list

Related Information

Product List

Product Name
RE12	for Cellbiology

For research use or further manufacturing use only. Not for use in diagnostic procedures.

Product content may differ from the actual image due to minor specification changes etc.

If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.