RE12

for Cellbiology

Specification Assay :: 98.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at -20 degrees C.

CAS RN^® :: 948891-46-1
Molecular Formula :: C29H45NO4
Molecular Weight :: 471.67

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Comparison	Product Number	Package Size	Price	Availability	Certificate of Analysis	Purchase
	Distributor 182-03051 Barcode No 4548995028341	1mg	List Price 356.00 USD	Out of Stock Inquire	Certificate of Analysis	Distributor

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Overview / Applications

Outline	This product is for research use only. Do not administer it to human. In many signal transduction cascades, phosphorylation (protein kinase) and dephosphorylation (protein phosphatase) of proteins are involved in cascade regulation. This product is an inhibitor that specifically inhibits protein phosphatase VHR (Vaccinia H1-related Phosphatase), a dual specific protein phosphatase targeting phosphorylated serine, threonine, and tyrosine. VHR has been confirmed to act on phosphorylated ERK and JNK in the MAP kinase cascade. Furthermore, its overexpression has been reported in cervical cancer and prostate cancer; for this reason, it has been attracting attention as a drug target. Inhibitory activity : IC50 = 1.6 umol/L (VHR) [>100 umol/L (CDC25A,CDC25B)] 1) Hirai, G. et al., "Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure.", ChemMedChem, 6(4), 617-622 (2011). 2) Tsuchiya, A. et al., "Dual-specificity phosphatase CDC25A/B inhibitor identified from a focused library with nonelectropholic core structure.", ACS Med. Chem. Lett., 3, 294-298 (2012).

Outline

This product is for research use only. Do not administer it to human.
In many signal transduction cascades, phosphorylation (protein kinase) and dephosphorylation (protein phosphatase) of proteins are involved in cascade regulation. This product is an inhibitor that specifically inhibits protein phosphatase VHR (Vaccinia H1-related Phosphatase), a dual specific protein phosphatase targeting phosphorylated serine, threonine, and tyrosine.
VHR has been confirmed to act on phosphorylated ERK and JNK in the MAP kinase cascade. Furthermore, its overexpression has been reported in cervical cancer and prostate cancer; for this reason, it has been attracting attention as a drug target.

Inhibitory activity : IC50 = 1.6 umol/L (VHR) [>100 umol/L (CDC25A,CDC25B)]

1) Hirai, G. et al., "Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure.", ChemMedChem, 6(4), 617-622 (2011).
2) Tsuchiya, A. et al., "Dual-specificity phosphatase CDC25A/B inhibitor identified from a focused library with nonelectropholic core structure.", ACS Med. Chem. Lett., 3, 294-298 (2012).

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5-(Hydroxymethyl)-3-[1-(3-methylbenzylamino)hexadecylidene]furan-2,4(3H,5H)-dione
2,4(3H,5H)-Furandione, 5-(hydroxymethyl)-3-[1-[[(3-methylphenyl)methyl]amino]hexadecylidene]-

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Product Name
RE44	for Cellbiology

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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