Dual-specific Protein Phosphatase Inhibitors

Phosphorylation and dephosphorylation occur in various proteins as post-translational modifications of proteins. Phosphorylation and dephosphorylation are intricately regulated and contribute to the control of signaling and enzymatic activity.

Protein phosphatases are enzymes that dephosphorylate phosphorylated proteins. They are classified into tyrosine phosphatases and serine/threonine phosphatases according to their specificity for amino acid residues. Dual (double)-specific protein phosphatases that act on tyrosine/serine/threonine are also known.

RE12 and RE44 are selective inhibitors of the dual-specific protein phosphatases VHR and CDC25B.


Target of inhibition:Vaccinia H1-related Phosphatase (VHR)

VHR is a phosphatase that dephosphorylates ERK1/2 and JNK1/2 of the MAPK family. It is attracting attention for its involvement in cell cycle regulation or as a target for development of anticancer drugs.


Target of inhibition:Cell Division Cycle 25 B (CDC25B)、Cell Division Cycle 25 A (CDC25A)

CDC25B and CDC25A are involved in the acceleration of cell cycle progression and checkpoint regulation for DNA damage. Increased expression has been reported in various cancer cells.

Product List

  • Open All
  • Close All

Related Product List

  • Open All
  • Close All

Protein Phosphatase Inhibitors

Kinase Activity Assay Kit

For research use or further manufacturing use only. Not for use in diagnostic procedures.

Product content may differ from the actual image due to minor specification changes etc.

If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.


Hours of Operation: 8:00 - 17:00 (EST)For other hours than the above, please contact us via the inquiry form.