FK506 Monohydrate

for Pharmacology Research

Specification Assay :: 98.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep below 25 degrees C.

CAS RN^® :: 109581-93-3
Molecular Formula :: C44H69NO12・H2O
Molecular Weight :: 822.03

GHS :

Citations (1)

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 063-06191 Barcode No 4548995018939	5mg	List Price 150.00 USD	In stock in Japan	Certificate of Analysis
	Distributor 069-06193 Barcode No 4548995018946	25mg	List Price 594.00 USD	In stock in Japan	Certificate of Analysis

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5mg
25mg

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Application

Overview / Applications

Outline	This product is for research use only. Do not administer it to human. FK506 is a potent immunosuppressant, neuroprotective agent and nerve regenerator. In vitro, FK506 has been shown to block T cell proliferation. Although it normally forms a complex with FK506 binding protein 12 (FKBP12), the molecule can also bind with calcineurin to downregulate the expression of various cytokines such as IL-2 and interferon, which subsequently leads to decreased extracellular T cell differentiation/proliferation.

Outline

This product is for research use only. Do not administer it to human.

FK506 is a potent immunosuppressant, neuroprotective agent and nerve regenerator. In vitro, FK506 has been shown to block T cell proliferation. Although it normally forms a complex with FK506 binding protein 12 (FKBP12), the molecule can also bind with calcineurin to downregulate the expression of various cytokines such as IL-2 and interferon, which subsequently leads to decreased extracellular T cell differentiation/proliferation.

Property

Appearance	White - nearly white, crystalline powder - powder

Manufacturer Information

Alias

Tacrolimus Monohydrate
(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-{(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl}-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone Monohydrate

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Product List

Product Name
Ciclosporin A	for Biochemistry
Everolimus (mixture of isomers)	for Cellbiology
FK506	for Biochemistry
Rapamycin (mixture of isomers)	for Cellbiology
Azathioprine Discontinued	for Biochemistry
Cyclophosphamide Monohydrate	for Biochemistry
Methotrexate	for Biochemistry
Mizoribine	for Pharmacology Research
Mycophenolic Acid	for Biochemistry

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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