For Alzheimer’s Disease Research

Fluorescent Probes for Senile Plaques and Neurofibrillary Tangles

These are small molecular fluorescent compounds which combine with senile plaques and neurofibrillary tangles.

You can easily and quickly stain senile plaques and neurofibrillary tangles with the probes. Staining process complete in 10 minutes.

Applications

  • BF-168

    Senile plaques-selective fluorescent probe
    Staining image of senile plaques with fluorescent probe BF-168.

    BF-168 can stain senile plaques similarly to Aβ antibody.

  • BF-170

    Neurofibrillary tangles-selective fluorescent probe
    Staining image of neurofibrillary tangles with fluorescent probe BF-170

    BF-170 can stain neurofibrillary tangles similarly to anti-phosphorylated Tau antibody.

BF-187

Senile plaques & neurofibrillary tangles dual target probe
Staining image of senile plaques and neurofibrillary tangles with fluorescent probe BF-187

Both senile plaques and neurofibrillary tangles are stained.

BF-188

Senile plaques & neurofibrillary tangles dual target probe (bicolor)
Staining image of senile plaques and neurofibrillary tangles with fluorescent probe BF-188

Senile plaques and neurofibrillary tangles are stained in different colors.

Arrows : Senile plaques
Arrowheads : Neurofibrillary tangles

Selection Guide

BF-168 BF-170 BF-187 BF-188
Summary Senile plaques selective Neurofibrillary tangles selective Senile plaques & neurofibrillary tangles
(Single color)
Senile plaques & neurofibrillary tangles
(Bicolor)
Senile plaques (Aβ) 〇 (Blue) 〇 (Green) 〇 (Green)
Neurofibrillary tangles (pTau) 〇 (Green) 〇 (Green) 〇 (Yellow, Red)
Excitation wavelength 380-420 nm 450-490 nm 400-440 nm 400-440 nm
Fluorescence wavelength 450 nm 520 nm 540 nm 380-420 nm
(Senile plaques)
510-560 nm
(Neurofibrillary tangles)
Chemical structure
References
  1. Okamura, N., et al.:Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J Neurosci.25,10857-10862(2005).
  2. Kuwabara, Y., et al.: Impairments of long-term depression induction and motor coordination precede Aβ accumulation in the cerebellum of APPswe/ PS1dE9 double transgenic mice, J. Neurochem., 130 (3), 432-443 (2014).
  1. Harada, R, et al.: Use of benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of Tau protein fibrils in the Alzheimer’s disease brain, Molecular Imaging and Biology, 16 (1), 19-27, 2014.
  1. Harada, R, et al.: Use of benzimidazole derivative BF-188 in fluorescence multispectral imaging for selective visualization of Tau protein fibrils in the Alzheimer’s disease brain, Molecular Imaging and Biology, 16 (1), 19-27, 2014.

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Amyloid β Antibodies

Total Tau Antibodies

Phosphorylated Tau Antibodies

Tau Isoform Antibodies

Product content may differ from the actual image due to minor specification changes etc.

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