DNA Methyltransferase Inhibitor(RG108)

DNA methyltransferase inhibitor, which different type compared with competitive inhibitor such as 5-Aza-2'-deoxycytidine, 5-Azacytidine, and zebularine. This compound would interact with the catalytical active core of DNA methyltransferase. Non-toxic for mammalian cells.
Article Brueckner B, et. al.: Cancer Res., 65, 6305 (2005).
Research for ES/iPS cell
Reagents for ES cell culture and iPS cell induction

• Maintain ES & iPs cells in an undifferentiated state


• Improve reprogramming efficiency

Controls in cell proliferation through low cytotoxicity.

Reference:

1. Tsumura, A., et al.: Genes Cells, 11, 805 (2006)