Procaine Hydrochloride

for Biochemistry

Specification Assay :: 99.0+% (HPLC)

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at RT.

CAS RN^® :: 51-05-8
Molecular Formula :: C13H20N2O2・HCl
Molecular Weight :: 272.77

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 167-15111 Barcode No 4987481318588	50g	List Price 61.00 USD	In stock in Japan	Certificate of Analysis

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Product Specification Sheet

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Application

Overview / Applications

Outline	Nerve cell membranes are charged negatively inside and positively outside in the static state with high extracellular concentrations of Na+ and Cl- and intracellular concentration of K+. However, upon excitation of cells, permeability of Na+ in the cell membrane is increased remarkably and inflow of a large amount of Na+ into cells changes ion distribution generating action potential accompanying depolarization. The excited site where action potential is generated transmits impulses by exciting adjacent static regions in succession. Local anesthetics block excitation conduction in the sensory nerve (anesthetic effect) by lowering Na+ permeability in cell membranes and inhibiting depolarization (stabilization of membrane) necessary for excitation.It has a local paralytic effect by paralyzing sensory nerve tissues and eliminating conduction function. Its toxicity is one sixth to one tenth that of cocaine, its mucosal permeability is weak, and it inhibits Na channels.It inhibits the maximum conductance of the Na+ channel. It causes a shift from the inactivation process to membrane potential-dependent depolarization.

Outline

Nerve cell membranes are charged negatively inside and positively outside in the static state with high extracellular concentrations of Na+ and Cl- and intracellular concentration of K+. However, upon excitation of cells, permeability of Na+ in the cell membrane is increased remarkably and inflow of a large amount of Na+ into cells changes ion distribution generating action potential accompanying depolarization. The excited site where action potential is generated transmits impulses by exciting adjacent static regions in succession. Local anesthetics block excitation conduction in the sensory nerve (anesthetic effect) by lowering Na+ permeability in cell membranes and inhibiting depolarization (stabilization of membrane) necessary for excitation.It has a local paralytic effect by paralyzing sensory nerve tissues and eliminating conduction function. Its toxicity is one sixth to one tenth that of cocaine, its mucosal permeability is weak, and it inhibits Na channels.It inhibits the maximum conductance of the Na+ channel. It causes a shift from the inactivation process to membrane potential-dependent depolarization.

Property

Appearance	White, crystals - crystalline powder
Melting Point	155 - 158 degrees C

Manufacturer Information

Alias

PROCAINE.HCL

Same CAS list

Related Information

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