It has been added to the cart.

It has been added to the comparison table.


for Organic Synthesis
Manufacturer :
FUJIFILM Wako Pure Chemical Corporation
Storage Condition :
Keep below 25 degrees C.
Molecular Weight :
  • Structural Formula
  • Label
  • Packing
Product Number
Package Size
Barcode No
List Price
550.00 USD

In stock in Japan


Product Specification Sheet
Spectral Data
Certificate of Analysis
Calibration Certificate

Product Summary

DMPS-Pt/AC-CP is a dimethylpolysilane (DMPS)-modified platinum catalyst supported on activated carbon (AC) and calcium phosphate (CP), which can be performed selective reduction of nitro groups and alkenes under liquid-phase continuous-flow conditions.



  • A novel dimethylpolysilane-modified Pt catalyst, supported on a mixture of activated carbon (AC), and calcium phosphate (CP).
  • Application for selective hydrogenation of nitro compounds and alkenes.


Selective reduction of nitro groups under continuous-flow conditions1

Examination of metal and second supports

In the reduction of 2-(p-chlorophenyl)nitromethane 1, DMPS-Pd/AC-CP and Pd/C fully reduced both chloro and nitro groups of 1 to give amine 2a (Table 1, entries 1 and 2), whereas DMPS-Pt/AC-CP reduced only the nitro groups to give amine 2b in high yields (Table 1, entry 3). The platinum catalyst with a different support than DMPS-Pt/AC-CP showed lower activity and selectivity (Table 1, entries 4 and 5).


Selective reduction of nitro group in the presence of benzyl ether

In the reduction of nitromethane 3 bearing benzyl ether, DMPS-Pd/AC-CP as a catalyst gave amine 4a reduced both nitro group and benzyl ether, while DMPS-Pt/AC-CP gave amine 4b reduced only the nitro group in high yield (Figure 1).


Synthesis of baclofen precursor

DMPS-Pt/AC-CP was applied to a part of the synthesis process (functional group selective reduction followed by cyclization) of the precursor 7 of baclofen 8 (Figure 2). Precursor 7 was obtained in 93-96% yield in 69 hours.


Reduction of alkenes under continuous-flow conditions1

Selective reduction of carvone

The reduction of (R)-carvone 9 using DMPS-Pt/AC-CP as a catalyst under optimized conditions of flow reaction afforded the desired unsaturated ketone 10 in high yield without saturated ketone 11 from over-reduction of 10 (Figure 3).


Synthesis of (S)-phellandrene

DMPS-Pt/AC-CP was applied to the first step (selective reduction of (R)-carvone 9) in the synthesis of (S)-phellandrene 12 (Figure 4). Hydrazone formation of the reducted product followed by Shapiro reaction gave (S)-phellandrene 12 in 80% yield.



  1. Ishitani, H., Furiya, Y., Kobayashi, S. : Chem. Asian J.,15, 1688 (2020).
  2. Miller, S. J., Ishitani, H., Furiya, Y., Kobayashi, S. : Org. Process Res. Dev., 25, 192 (2021).

Overview / Applications


Appearance Black powder

Manufacturer Information


For research use or further manufacturing use only. Not for use in diagnostic procedures.

Product content may differ from the actual image due to minor specification changes etc.

If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.


Hours of Operation: 8:00 - 17:00 (EST)For other hours than the above, please contact us via the inquiry form.