Deuterated Compounds/Deuterated-Alkylation Reagents
Deuterium has approximately double the mass of regular hydrogen (protium). Because C-D bonds are stronger than C-H bonds, this property is being actively explored in pharmaceutical and electronic materials research.
FUJIFILM Wako offers a selection of deuterated building blocks and reagents for organic synthesis. A custom synthesis service is also available for customers seeking deuteration of specific compounds. Utilizing the hydrogen-deuterium exchange technology developed in-house enables the cost-effective and large-scale supply of the desired deuterated compounds.
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Key properties of deuterium include:
- Approximately double the mass of regular hydrogen (protium)
- Although the natural isotopic abundance is only 0.015%, deuterium is relatively easy to obtain due to the abundance of hydrogen itself
- Readily detectable by NMR, mass spectrometry, and other analytical methods
- A stable, non-radioactive isotope that requires no special facilities or expertise to handle
- Its chemical properties are fundamentally similar to those of protium, although reaction rates are often somewhat slower — a property known as the kinetic isotope effect (deuterium effect)
As deuterated compounds have come into wider use, there is growing demand for methods to introduce deuterium at specific positions within molecules. Methods commonly used include: deprotonation with a base to generate a nucleophile, followed by reaction with deuterium oxide (D2O); using pre-deuterated building blocks such as bromobenzene-d5 and iodomethane-d3; and using deuterated reducing agents such as LiAlD4 and NaBD4.
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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