Polyclonal antibodies for optic nerve research
Optic Nerve-related Antibodies
Polyclonal antibodies to factors involved in the development and function of optic nerves.
Features
- Performances of each antibody has been demonstrated within KO mice
- Applications are available
Antibody Information
| Anti Mouse 4.1G / EPB41L2, Rabbit | Anti Mouse ICK, Guinea Pig | Anti Mouse Mak, Guinea Pig | Anti Mouse Trβ2, Rabbit | |
|---|---|---|---|---|
| Wako Cat. No. | 018-26421 | 015-26431 | 012-26441 | 016-24261 |
| Antigen | Synthetic peptide TPRLRKRGKDPSENRGIC (57-73 a.a.) of 4.1G/EPB41L2 |
Synthetic peptide corresponding to 346-412 a.a. of ICK |
His-tagged C-terminal sequence (296-622 a.a.) of mouse Mak |
Recombinant mouse Trβ2 N-terminal fragment (1-107 a.a.) |
| Antigen factor information |
4.1G (Alias: EPB41L2) is one of the ERM family proteins with a molecular weight about 113 kDa. It preserves the formation of cytoplasmic membranve. Recently, it is reported to regulate synaptic location in the retina and normal visuality by using KO mouse. It is also used as a rod cell marker. | ICK (Alias: MRK, LCK2) is a kinase protein with a molecular weight about 71 kDa. It localizes at the tip of cilia regulating cliliary transport. ICK phosphorylates Kif3a and essential for proper cliliogenesis. | Mak (Alias: DJ417M14.2) is a kinase protein with a molecular weight of 71 kDa. It regulates ciliary length by phosphorylating RP1. | Trβ2 (Thyroid hormone receptor beta 2) is a high affinity receptor for triiodothyronine. Trβ2 is required for the development of green cone photoreceptors of embryonic retina. It is also used as a cone cell marker. |
| Host / Isotype | Rabbit / IgG | Guinea pig / IgG | Guinea pig / IgG | Rabbit / IgG |
| Species cross reactivity | Mouse (Other species have not been tested) |
Mouse (Other species have not been tested) |
Mouse (Other species have not been tested) |
Mouse (Other species have not been tested) |
| Applications | ■Immunocytochemistry 1 : 5,000 - 10,000 ■Western Blot 1 : 10,000 - 100,000 |
■Immunocytochemistry 1 : 100 ■Western Blot 1 : 250 |
■Immunocytochemistry 1 : 1,000 ■Western Blot 1 : 3,000 |
■Immunocytochemistry 1 : 1,000 ■Western Blot 1 : 1,000 |
| Application data (Immuno-cytochemistry) |
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| References | Sanuki, R., et al.: Cell Reports, 10, 796 (2015). | Chaya, T., et al.: The EMBO Journal, 33,1227 (2014). | Omori, Y., et al.: Proc. Natl. Acad. Sci. 107, 22671 (2010). | Sanuki, R., et al.: Nature Neurosci., 14, 1125 (2011). |
Data was provided by Takahisa Furukawa, Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University.
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For research use or further manufacturing use only. Not for use in diagnostic procedures.
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