for Study of Natural Immunity and Self-protection Mechanism

LPS (Lipopolysaccharides)

Lipopolysaccharide (LPS) is present in the outer membrane of Gram-negative bacteria. It plays an important role in a number of bioactivities and cell-cell communication. In recent years, LPS is used in vigorous research of natural immunity and self-protection mechanism. our LPS product line will prove useful in induction of different inflammatory responses.
LPS from E. coli is used as an antigen for diagnosis of enterohemorrhagic E. coli infection.
Campylobacter jejuni is a potential etiological factor of Guillain-Barre syndrome, and LPS from Campylobacter jejuni derives from Campylobacter extracted from patients with Guillain-Barre syndrome.
Research has shown that the O-antigen within LPS in Rickettsia and Proteus bacteria share the same structure. LPS from three Proteus bacteria are used as antigens for Weil-Felix test, an agglutination test for the diagnosis of Rickettsia infection (rash, epidemic typhus, and scrub typhus).
P. aeruginosa is relatively resistant to antibiotics and is raising issues as a pathogen of nosocomial infections and opportunistic infections.
Bordetella pertussis is a causative agent of whooping cough which is one of respiratory tract infections. The LPS of Bordetella pertussis, unlike the LPS of E. coli, lacks O-antigens.


We have two types of products prepared by different methods.

[Phenol extraction] Extracted by the Westphal method (using phenol)

[Ultracentrifugation] Those extracted with phenol are purified twice by ultracentrifugation

Product Lineup

E. coli  O26、O55、O86a、O103、O111、O113、O127、O128、O150、O157

Campylobacter jejuni  Penner O:19

Salmonella typhimuriumSalmonella typhimurium G30/C21

Salmonella minnesota  1114、R595

Proteus vulgaris  OX2、OX19

Proteus mirabillis  OXK

Pseudomonas aeruginosa  PAO1

Bordetella pertussis  Tohama


Desaki, Y. et al.. : Plant Cell Physiol., 47(11), 1530(2006).

Ueda, Y. et al. : Anticancer Res., 26, 4063(2006).

Kamachi, F. et al. : J. Pharmacol. Exp. Ther., 321(1), 345(2007).

Soliman, M. M. et al. : Asian J. Biochem., 4(2), 60(2009).

Kono, K. et al. : Am. J. Physiol. Renal Physiol., 296, F328(2009).

Sritularak, B. et al. : J. Med. Plant. Res., 4(5), 387(2010).

Kobayashi, H. et al. : Microbiol. Res., 167, 48(2011).

Sato, K. et al. : Glycative Stress Research, 1(1), 1(2014).

Miyashita, A. et al. : J. Biol. Chem., 289, 14412(2014).

Shi, M. et al. : Food Chem., 155, 50(2014).

Mori, R. et al. : Am. J. Pathol., 184, 2465(2014).

Nagasaki, T. et al. : Br. J. Cancer, 110, 469(2014).

Shintani, M. et al. : Food Nutr. Sci., 6, 1115(2015).

Kishimoto, M. et al. : Biosci. Microbiota Food Health, 34, 11(2015).

Custom-made LPS

We offer contract production of LPS from Gram-negative bacteria not shown below.
Contact us or sales representative at one of our distributors.

Product List

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Escherichia coli (Phenol extraction)

Escherichia coli (Ultracentrifugation)

Campylobacter jejuni (Phenol extraction)

Salmonella (Ultracentrifugation)

Proteus (Phenol extraction)

Pseudomonas aeruginosa (Ultracentrifugation)

Bordetella pertussis (Ultracentrifugation)

For research use or further manufacturing use only. Not for use in diagnostic procedures.

Product content may differ from the actual image due to minor specification changes etc.

If the revision of product standards and packaging standards has been made, there is a case where the actual product specifications and images are different.


Hours of Operation: 8:00 - 17:00 (EST)For other hours than the above, please contact us via the inquiry form.