Orexin Related Compounds

Orexin is a neuropeptide produced by certain nerve cells in the lateral hypothalamus.

There are two types of orexin, orexin A and orexin B, both of which are endogenous agonists at orexin receptors. There are two subtypes of orexin receptor, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R). Compared to its affinity for orexin B, OX1R shows approximately 50 times greater affinity for orexin A. The affinity of OX2R for orexin A and B is approximately equal.

In particular, OX2R plays essential roles in the regulation of sleep and arousal. It has been revealed that lack of orexin in the brain is the cause of narcolepsy, a sleep disorder.

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Orexin Receptor Agonists

Orexin Receptor Antagonists

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