ペプチド医薬品の品質保証に
ペプチド治療薬API (医薬品原薬) 不純物
ペプチド治療薬の医薬品原薬 (API) の構成要素には、目的物質の他、精製工程で完全に除去することのできない製造工程由来の不純物や、保管中に目的物質が分解して生じる目的物質由来の不純物が含まれます。通常、製造工程由来の不純物はラセミ化、脱アミド化、酸化やアスパルチミド形成等ペプチド合成時に生じる副反応生成物ですが、固相合成の場合には、アミノ酸欠失やアミノ酸挿入によって生成する類似体も含まれます。これらの化合物の標準物質は、関連する薬局方で求められる不純物の規格を満たすため、そして何よりも、医薬品原薬 (API) の品質保証のための分析法の開発やリリース試験に必要です。
本ページでは、ペプチド医薬品原薬 (API) の一般的な不純物や欧州薬局方の医薬品各条 (モノグラフ) に記載されている化合物をご紹介します。高品質なペプチドで国内外で信頼されている、ペプチド研究所とBachem社の製品です。
ペプチド医薬品 類縁物質標品の合成サービス：ペプチド研究所
⼀般的に不純物ペプチドの合成は主成分ペプチドの合成よりも難度が⾼いのが実情です。 ペプチド研究所は、 前身の蛋白質研究奨励会より受け継がれたペプチド合成と精製、および分析技術を駆使して高品質のペプチド製品を長年にわたり供給しており、これら難度の⾼い不純物ペプチドのカスタム合成も可能です。
カスタム合成例
- Asp-X、Asn-X：Succinimide化、β-Asp-X (iso-Asp-X)
- Cys残基の酸化：スルフィン酸［Cys(O2H)］、スルフォン酸［Cys(O3H)］、ジスルフィド形成 (dimer形成)
- Met残基の酸化：スルフォキシド［Met(O)］、スルフォン［Met(O2)］
- N末端 Gln、Glu：ピログルタミン酸 (Pyr) 化
- 加水分解：Asn、Gln、C末アミドのデアミド化、エステルの加水分解、ペプチド結合の加水分解
- アルキル化：Met、Cys、Tyr、Trp、His 残基などのアルキル化
- アシル化：Ser、Thr、Tyr 残基などのアシル (Acなど) 化、末端アミノ基やLys残基などのアシル化
- その他：短鎖、欠損、重複、ラセミ化 (D体化)、枝分かれ (分岐) ペプチド。ジスルフィド結合異性体など
ペプチド医薬品原薬 (API) 不純物のラインアップ
Atosiban (アトシバン)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| Atosiban (free acid) trifluoroacetate salt | Antocin (free acid), (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin (free acid) | 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-OH trifluoroacetate salt (Disulfide bond) | Bachem | 4083914 |
| Atosiban (1-8) lactam | 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-lactam (Disulfide bond) | Bachem | 4081127 | |
| (Orn(Ac)8)-Atosiban | 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn(Ac)-Gly-NH2 (Disulfide bond) | Bachem | 4081126 | |
| (Orn(Atosiban (free acid))8)-Atosiban trifluoroacetate salt | Atosiban (Dimer) | 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn(Gly-Orn-Pro-Cys-Asn-Thr-Ile-D-Tyr(Et)-3-mercaptopropionyl)-Gly-NH2 trifluoroacetate salt (Disulfide bonds between 3-Mercaptopropionyl A and Cys A/Cys B and 3-Mercaptopropionyl B) | Bachem | 4083915 |
| Atosiban acetate salt | (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin, RWJ 22164 | 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 acetate salt (Disulfide bond) | Bachem | 4065438 |
Buserelin (ブセレリン)：欧州薬局方医薬品各条 (モノグラフ) 掲載
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH acetate salt | [DSer(tBu)6, Des-Gly10] LH-RH, Ethyl Amide, Buserelin | Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt | Bachem | 4028150 |
Exenatide (エキセナチド)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (D-Asn28)-Exenatide trifluoroacetate salt | (D-Asn28)-Exendin-4 trifluoroacetate salt | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4084643 |
| (Asp28)-Exenatide trifluoroacetate salt | (Asp28)-Exendin-4 | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asp-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4085312 |
| (D-Asp28)-Exenatide trifluoroacetate salt | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asp-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4085313 | |
| (β-Asp28)-Exenatide trifluoroacetate salt | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asp(Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2)-OH trifluoroacetate salt | Bachem | 4085314 | |
| (β-D-Asp28)-Exenatide trifluoroacetate salt | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asp(Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2)-OH trifluoroacetate salt | Bachem | 4085315 | |
| (D-His1)-Exenatide trifluoroacetate salt | (D-His1)-Exendin-4 | H-D-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4072224 |
| Met(O)14-Exenatide trifluoroacetate salt | Met(O)14-Exendin-4 | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met(O)-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4082706 |
| Acetyl-Exenatide trifluoroacetate salt | Acetyl-Exendin-4 | Ac-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4072222 |
| (Des-Gly2)-Exenatide trifluoroacetate salt | (Des-Gly2)-Exendin-4 | H-His-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4072221 |
| Endo-38a-Pro-Exenatide trifluoroacetate salt | Endo-38a-Exendin-4 | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt | Bachem | 4072223 |
| Exenatide acetate salt | Exendin-4 | H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 acetate salt | Bachem | 4019602 |
Glucagon (グルカゴン)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (Asp28)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt | H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asp-Thr-OH trifluoroacetate salt | Bachem | 4079056 | |
| (Glu3)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt | H-His-Ser-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt | Bachem | 4079054 | |
| (Glu20)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt | H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Glu-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt | Bachem | 4079055 | |
| (Glu24)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt | H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Glu-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt | Bachem | 4071253 | |
| (Des-Thr5)-Glucagon trifluoroacetate salt | H-His-Ser-Gln-Gly-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt | Bachem | 4045345 | |
| (Des-Thr7)-Glucagon trifluoroacetate salt | H-His-Ser-Gln-Gly-Thr-Phe-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt | Bachem | 4045365 | |
| (Met(O)27)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt | H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met(O)-Asn-Thr-OH trifluoroacetate salt | Bachem | 4043506 | |
| Glucagon (1-29) (human, rat, porcine) | Glucagon, human | H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH | Bachem | 4033017 |
| Glucagon (Human) | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr | ペプチド研究所 | 4098-s |
Gonadorelin (ゴナドレリン)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| LHRH (free acid) trifluoroacetate salt | GnRH (free acid), Gonadorelin (free acid), LH-RH, Free Acid | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH trifluoroacetate salt | Bachem | 4009735 |
| (D-Leu7)-LHRH trifluoroacetate salt | (D-Leu7)-Gonadorelin | Pyr-His-Trp-Ser-Tyr-Gly-D-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt | Bachem | 4041861 |
| LHRH (1-5) (free acid) trifluoroacetate salt | Pyr-His-Trp-Ser-Tyr-OH trifluoroacetate salt | Bachem | 4028309 | |
| LHRH acetate salt | Gonadorelin, LH-RH, human, GnRH, Luliberin | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 acetate salt | Bachem | 4033013 |
| LH-RH (Human) | Luteinizing Hormone Releasing Hormone (Human) , Gonadotropin-Releasing Hormone | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 · 2AcOH · 4H2O | ペプチド研究所 | 4013 |
| LH-RH (Human) | Luteinizing Hormone Releasing Hormone (Human) , Gonadotropin-Releasing Hormone | Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 | ペプチド研究所 | 4013-v |
Goserelin (ゴセレリン)：欧州薬局方医薬品各条 (モノグラフ) 掲載
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity A |
(D-Ser4)-Goserelin | Pyr-His-Trp-D-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 trifluoroacetate salt | Bachem | 4035304 |
| (Ser(tBu)6,Azagly10)-LHRH 欧州薬局方医薬品各条 (モノグラフ)：Impurity B |
(Ser(tBu)6)-Goserelin | Pyr-His-Trp-Ser-Tyr-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 | Bachem | 4035307 |
| (Des-Gly10,D-Ser(tBu)6,Pro-NHNH29)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity E |
(Pro-NHNH29)-Buserelin, Decarbamoylgoserelin, (Des-carboxamide)-Goserelin | Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNH2 trifluoroacetate salt | Bachem | 4039400 |
| (D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH 欧州薬局方医薬品各条 (モノグラフ)：Impurity F |
(D-Tyr5)-Goserelin | Pyr-His-Trp-Ser-D-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 | Bachem | 4035302 |
| (D-His2,D-Ser(tBu)6,Azagly10)-LHRH 欧州薬局方医薬品各条 (モノグラフ)：Impurity G |
(D-His2)-Goserelin | Pyr-D-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 | Bachem | 4035303 |
| (Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity K |
(Ser(Ac)4)-Goserelin | Pyr-His-Trp-Ser(Ac)-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 trifluoroacetate salt | Bachem | 4054732 |
| (D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH 欧州薬局方医薬品各条 (モノグラフ)：Impurity L |
(D-Leu7)-Goserelin | Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-D-Leu-Arg-Pro-Azagly-NH2 | Bachem | 4037082 |
| (D-Ser(tBu)6,Azagly10)-LHRH acetate salt | [DSer(tBu)6, (Aza)Gly10] LH-RH, Goserelin | Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 acetate salt | Bachem | 4038252 |
Histrelin (ヒストレリン)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH | (D-His2)-Histrelin | Pyr-D-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt | Bachem | 4028762 |
| (Des-Gly10,D-His(Bzl)6,Pro-NHEt9)-LHRH acetate salt | Histrelin | Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt | Bachem | 4035442 |
Leuprorelin (リュープロレリン)：欧州薬局方医薬品各条 (モノグラフ) 掲載
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (Des-Gly10,D-Ser4,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity A |
(D-Ser4)-Leuprolide, (D-Ser4)-Leuprorelin, (Des-Gly10, DSer4, DLeu6, Pro-NHEt9)-LHRH | Pyr-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt | Bachem | 4033803 |
| (Des-Gly10,D-His2,D-Leu6,Pro-NHEt9)-LHRH 欧州薬局方医薬品各条 (モノグラフ)：Impurity B |
(D-His2)-Leuprolide, (D-His2)-Leuprorelin | Pyr-D-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt | Bachem | 4028311 |
| (Des-Gly10,Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity C |
(Leu6)-Leuprolide, (Leu6)-Leuprorelin | Pyr-His-Trp-Ser-Tyr-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt | Bachem | 4033802 |
| (Des-Gly10,Ser(Ac)4,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity D |
(Ser(Ac)4)-Leuprolide, (Ser(Ac)4)-Leuprorelin | Pyr-His-Trp-Ser(Ac)-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt | Bachem | 4034724 |
| (Des-Gly10,D-Trp3,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity E |
(D-Trp3)-Leuprorelin, (D-Trp3)-Leuprolide | Pyr-His-D-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt | Bachem | 4058815 |
| (Des-Gly10,D-His2,D-Ser4,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity F |
(D-His2,D-Ser4)-Leuprorelin, (D-His2,D-Ser4)-Leuprolide | Pyr-D-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt | Bachem | 4048380 |
| (Des-Gly10,D-Tyr5,D-Leu6,Pro-NHEt9)-LHRH 欧州薬局方医薬品各条 (モノグラフ)：Impurity G |
(D-Tyr5)-Leuprolide, (D-Tyr5)-Leuprorelin | Pyr-His-Trp-Ser-D-Tyr-D-Leu-Leu-Arg-Pro-NHEt | Bachem | 4028312 |
| (Des-Gly10,D-Leu6,D-Leu7,Pro-NHEt9)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity H |
(D-Leu7)-Leuprolide, (D-Leu7)-Leuprorelin | Pyr-His-Trp-Ser-Tyr-D-Leu-D-Leu-Arg-Pro-NHEt trifluoroacetate salt | Bachem | 4028310 |
| (Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt 欧州薬局方医薬品各条 (モノグラフ)：Impurity I |
(D-Pyr1)-Leuprorelin, (D-Pyr1)-Leuprolide | D-Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt | Bachem | 4046113 |
| (Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH trifluoroacetate salt | (Orn8)-Leuprorelin, (Orn8)-Leuprolide | Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Orn-Pro-NHEt trifluoroacetate salt | Bachem | 4065128 |
| (Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH acetate salt | Leuprolide, Leuprorelin, [Des-Gly10, DLeu6, Pro9] LH-RH, Ethyl Amide | Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate salt | Bachem | 4033014 |
Octreotide (オクトレオチド)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| Acetyl-Octreotide acetate salt | Ac-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol acetate salt (Disulfide bond) | Bachem | 4071290 | |
| (Cys(S)2)-Octreotide trifluoroacetate salt | H-D-Phe-Cys(S)-Phe-D-Trp-Lys-Thr-Cys-L-threoninol trifluoroacetate salt (Trisulfide bond) | Bachem | 4071291 | |
| (D-Cys7,des-L-threoninol8)-Octreotide acetate salt | H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-D-Cys-OH acetate salt (Disulfide bond) | Bachem | 4099464 | |
| (Des-L-threoninol8)-Octreotide amide acetate salt | H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-NH₂ acetate salt (Disulfide bond) | Bachem | 4099462 | |
| (L-Threoninol(Ac)8)-Octreotide acetate salt | H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol(Ac) acetate salt (Disulfide bond) | Bachem | 4099463 | |
| (Lys(Ac)5)-Octreotide acetate salt | H-D-Phe-Cys-Phe-D-Trp-Lys(Ac)-Thr-Cys-L-threoninol acetate salt (Disulfide bond) | Bachem | 4099465 | |
| Octreotide acetate salt | SMS 201-995, (D-Phe5,Cys6.11,D-Trp8,L-Threoninol12)-Somatostatin-14 (5-12) | H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol acetate salt (Disulfide bond) | Bachem | 4042822 |
| Octreotide trifluoroacetate salt (Dimer, Antiparallel) | (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol)2 trifluoroacetate salt (Disulfide bonds between Cys2A and Cys7B/Cys7A and Cys2B) | Bachem | 4080984 | |
| Octreotide trifluoroacetate salt (Dimer, Parallel) | (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol)2 trifluoroacetate salt (Disulfide bonds between Cys2A and Cys2B/Cys7A and Cys7B) | Bachem | 4080983 |
Teriparatide (テリパラチド)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| pTH (2-34) (human) acetate salt | H-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH acetate salt | Bachem | 4069253 | |
| pTH (1-34) (human) acetate salt | Teriparatide, Parathyroid Hormone (1-34), human | H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH acetate salt | Bachem | 4011474 |
| Parathyroid Hormone (Human, 1-34) | PTH (Human, 1-34) | Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe | ペプチド研究所 | 4068-s |
| Parathyroid Hormone (Human, 1-34) | PTH (Human, 1-34) | Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe | ペプチド研究所 | 4068-v |
Tetracosactide (Cosyntropin) (テトラコサクチド(コシントロピン))
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (D-Lys16)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt | (D-Lys16)-ACTH (1-24) human, bovine, mouse, ovine, porcine, rabbit, rat, (D-Lys16)-Tetracosactide | H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-D-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4033149 |
| (D-Ser1)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt | (DSer1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat), (D-Ser1)-Tetracosactide | H-D-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4029278 |
| (Des-Glu5)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt | (Des-Glu5)-Tetracosactide | H-Ser-Tyr-Ser-Met-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4063587 |
| (Des-His6)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt | (Des-His6)-Tetracosactide | H-Ser-Tyr-Ser-Met-Glu-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4063586 |
| (Des-Ser3)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt | (Des-Ser3)-Tetracosactide | H-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4059984 |
| Endo-4a-Glu-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt | Endo-4a-Glu-Tetracosactide | H-Ser-Tyr-Ser-Met-Glu-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4063588 |
| ACTH (2-24) (human, bovine, rat) trifluoroacetate salt | Corticotropin (2-24), Tetracosactide (2-24) | H-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4059983 |
| Acetyl-ACTH (3-24) (human, bovine, rat) trifluoroacetate salt | Acetyl-Tetracosactide (3-24) | Ac-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4059986 |
| Acetyl-ACTH (7-24) (human, bovine, rat) trifluoroacetate salt | Acetyl-Tetracosactide (7-24) | Ac-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4062898 |
| ACTH (1-24) (human, bovine, rat) trifluoroacetate salt | Cosyntropin, Tetracosactide, Tetracosactrin | H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt | Bachem | 4011958 |
| ACTH (Human, 1-24) | Adrenocorticotropic Hormone (Human, 1-24) | Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro | ペプチド研究所 | 4109-v |
Triptorelin (トリプトレリン)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| (D-Trp6)-LHRH (free acid) trifluoroacetate salt | Triptorelin (free acid) | Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-OH trifluoroacetate salt | Bachem | 4026526 |
| (D-Trp6,D-Leu7)-LHRH trifluoroacetate salt | (D-Leu7)-Triptorelin | Pyr-His-Trp-Ser-Tyr-D-Trp-D-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt | Bachem | 4025366 |
| (D-Ser4,D-Trp6)-LHRH trifluoroacetate salt | (D-Ser4)-Triptorelin | Pyr-His-Trp-D-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt | Bachem | 4025363 |
| (D-Tyr5,D-Trp6)-LHRH trifluoroacetate salt | (D-Tyr5)-Triptorelin | Pyr-His-Trp-Ser-D-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt | Bachem | 4025365 |
| (D-Trp6)-LHRH acetate salt | Triptorelin acetate salt, (D-Trp6)-GnRH, [DTrp6] LH-RH, amide | Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 acetate salt | Bachem | 4033016 |
| (D-Trp6)-LHRH pamoate salt | Triptorelin pamoate salt | Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 pamoate salt | Bachem | 4039648 |
Antazoline (アンタゾリン)
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| N-(2-Aminoethyl)-2-(benzylphenylamino)acetamide · maleate | N-Aminoethyl-(N-benzylanilino)acetamide · maleate, N-Phenyl-N-Bzl-Gly-2-aminoethylamide · maleate | Bachem | 4028954 | |
| 2-(N-Phenyl-N-benzyl-aminomethyl)-imidazole | N-Benzyl-N-(1H-imidazol-2-ylmethyl)-aniline, Benzyl-(1H-imidazol-2-ylmethyl)-phenyl-amine | Bachem | 4052755 | |
| Antazoline · 0.5 H2SO4 | Benzyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenyl-amine · 0.5 H2SO4 | 2-(N-Phenyl-N-benzyl-aminomethyl)-imidazoline · 0.5 H2SO4 | Bachem | 4041457 |
L-Alanyl-L-Glutamine (L-アラニル-L-グルタミン (静脈栄養))
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| H-Ala-D-Gln-OH | Bachem | 4011868 | ||
| H-D-Ala-Gln-OH | Bachem | 4011870 | ||
| H-Ala-Glu-OH | Bachem | 4002318 | ||
| H-Ala-Ala-Gln-OH | Bachem | 4026080 | ||
| Cyclo(-Ala-Gln) | Bachem | 4035535 | ||
| Cyclo(-Ala-Glu) | Bachem | 4035536 | ||
| H-Ala-Gln-OH | Bachem | 4003766 |
Aspartame (アスパルテーム)：欧州薬局方医薬品各条 (モノグラフ) 掲載
| 品名 | 別名 | シークエンス | メーカー | メーカーコード |
|---|---|---|---|---|
| Cyclo(-Asp-Phe) 欧州薬局方医薬品各条 (モノグラフ)：Impurity A |
(2S,5S)-5-Benzyl-3,6-dioxo2-piperazineacetic acid, Aspartame-Related Compound A | Bachem | 4016611 | |
| H-Asp-Phe-OH 欧州薬局方医薬品各条 (モノグラフ)：Impurity B |
Bachem | 4001477 | ||
| H-Phe-OH 欧州薬局方医薬品各条 (モノグラフ)：Impurity C |
Bachem | 4031148 | ||
| Aspartame | H-Asp-Phe-OMe | Bachem | 4000411 |
製品一覧
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甘味料 (医薬品添加物)
抗悪性腫瘍薬、性腺刺激ホルモン放出ホルモン受容体作動薬
抗アレルギー薬、ヒスタミンH1受容体拮抗薬
骨吸収抑制薬、骨粗鬆症治療薬、副甲状腺ホルモン受容体作動薬
子宮収縮抑制薬、オキシトシン受容体拮抗薬
静脈栄養
糖尿病治療薬、診断薬、グルカゴン受容体作動薬
糖尿病治療薬、グルカゴン様ペプチド1 (GLP-1) 受容体作動薬
副腎皮質刺激ホルモン
ホルモン分泌抑制薬、ソマトスタチン受容体作動薬
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