ペプチド医薬品の品質保証に

ペプチド治療薬API (医薬品原薬) 不純物

ペプチド治療薬の医薬品原薬 (API) の構成要素には、目的物質の他、精製工程で完全に除去することのできない製造工程由来の不純物や、保管中に目的物質が分解して生じる目的物質由来の不純物が含まれます。通常、製造工程由来の不純物はラセミ化、脱アミド化、酸化やアスパルチミド形成等ペプチド合成時に生じる副反応生成物ですが、固相合成の場合には、アミノ酸欠失やアミノ酸挿入によって生成する類似体も含まれます。これらの化合物の標準物質は、関連する薬局方で求められる不純物の規格を満たすため、そして何よりも、医薬品原薬 (API) の品質保証のための分析法の開発やリリース試験に必要です。

本ページでは、ペプチド医薬品原薬 (API) の一般的な不純物や欧州薬局方の医薬品各条 (モノグラフ) に記載されている化合物をご紹介します。高品質なペプチドで国内外で信頼されている、ペプチド研究所とBachem社の製品です。

ペプチド医薬品 類縁物質標品の合成サービス:ペプチド研究所

⼀般的に不純物ペプチドの合成は主成分ペプチドの合成よりも難度が⾼いのが実情です。 ペプチド研究所は、 前身の蛋白質研究奨励会より受け継がれたペプチド合成と精製、および分析技術を駆使して高品質のペプチド製品を長年にわたり供給しており、これら難度の⾼い不純物ペプチドのカスタム合成も可能です。

カスタム合成例

  • Asp-X、Asn-X:Succinimide化、β-Asp-X (iso-Asp-X)
  • Cys残基の酸化:スルフィン酸[Cys(O2H)]、スルフォン酸[Cys(O3H)]、ジスルフィド形成 (dimer形成)
  • Met残基の酸化:スルフォキシド[Met(O)]、スルフォン[Met(O2)]
  • N末端 Gln、Glu:ピログルタミン酸 (Pyr) 化
  • 加水分解:Asn、Gln、C末アミドのデアミド化、エステルの加水分解、ペプチド結合の加水分解
  • アルキル化:Met、Cys、Tyr、Trp、His 残基などのアルキル化
  • アシル化:Ser、Thr、Tyr 残基などのアシル (Acなど) 化、末端アミノ基やLys残基などのアシル化
  • その他:短鎖、欠損、重複、ラセミ化 (D体化)、枝分かれ (分岐) ペプチド。ジスルフィド結合異性体など

ペプチド医薬品原薬 (API) 不純物のラインアップ

Atosiban (アトシバン)

品名 別名 シークエンス メーカー メーカーコード
Atosiban (free acid) trifluoroacetate salt Antocin (free acid), (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin (free acid) 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-OH trifluoroacetate salt (Disulfide bond) Bachem 4083914
Atosiban (1-8) lactam 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-lactam (Disulfide bond) Bachem 4081127
(Orn(Ac)8)-Atosiban 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn(Ac)-Gly-NH2 (Disulfide bond) Bachem 4081126
(Orn(Atosiban (free acid))8)-Atosiban trifluoroacetate salt Atosiban (Dimer) 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn(Gly-Orn-Pro-Cys-Asn-Thr-Ile-D-Tyr(Et)-3-mercaptopropionyl)-Gly-NH2 trifluoroacetate salt (Disulfide bonds between 3-Mercaptopropionyl A and Cys A/Cys B and 3-Mercaptopropionyl B) Bachem 4083915
Atosiban acetate salt (Deamino-Cys1,D-Tyr(Et)2,Thr4,Orn8)-Oxytocin, RWJ 22164 3-Mercaptopropionyl-D-Tyr(Et)-Ile-Thr-Asn-Cys-Pro-Orn-Gly-NH2 acetate salt (Disulfide bond) Bachem 4065438

Buserelin (ブセレリン):欧州薬局方医薬品各条 (モノグラフ) 掲載

品名 別名 シークエンス メーカー メーカーコード
(Des-Gly10,D-Ser(tBu)6,Pro-NHEt9)-LHRH acetate salt [DSer(tBu)6, Des-Gly10] LH-RH, Ethyl Amide, Buserelin Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHEt acetate salt Bachem 4028150

Exenatide (エキセナチド)

品名 別名 シークエンス メーカー メーカーコード
(D-Asn28)-Exenatide trifluoroacetate salt (D-Asn28)-Exendin-4 trifluoroacetate salt H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4084643
(Asp28)-Exenatide trifluoroacetate salt (Asp28)-Exendin-4 H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asp-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4085312
(D-Asp28)-Exenatide trifluoroacetate salt H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asp-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4085313
(β-Asp28)-Exenatide trifluoroacetate salt H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asp(Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2)-OH trifluoroacetate salt Bachem 4085314
(β-D-Asp28)-Exenatide trifluoroacetate salt H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-D-Asp(Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2)-OH trifluoroacetate salt Bachem 4085315
(D-His1)-Exenatide trifluoroacetate salt (D-His1)-Exendin-4 H-D-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4072224
Met(O)14-Exenatide trifluoroacetate salt Met(O)14-Exendin-4 H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met(O)-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4082706
Acetyl-Exenatide trifluoroacetate salt Acetyl-Exendin-4 Ac-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4072222
(Des-Gly2)-Exenatide trifluoroacetate salt (Des-Gly2)-Exendin-4 H-His-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4072221
Endo-38a-Pro-Exenatide trifluoroacetate salt Endo-38a-Exendin-4 H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Pro-Ser-NH2 trifluoroacetate salt Bachem 4072223
Exenatide acetate salt Exendin-4 H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 acetate salt Bachem 4019602

Glucagon (グルカゴン)

品名 別名 シークエンス メーカー メーカーコード
(Asp28)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asp-Thr-OH trifluoroacetate salt Bachem 4079056
(Glu3)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt H-His-Ser-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt Bachem 4079054
(Glu20)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Glu-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt Bachem 4079055
(Glu24)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Glu-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt Bachem 4071253
(Des-Thr5)-Glucagon trifluoroacetate salt H-His-Ser-Gln-Gly-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt Bachem 4045345
(Des-Thr7)-Glucagon trifluoroacetate salt H-His-Ser-Gln-Gly-Thr-Phe-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH trifluoroacetate salt Bachem 4045365
(Met(O)27)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met(O)-Asn-Thr-OH trifluoroacetate salt Bachem 4043506
Glucagon (1-29) (human, rat, porcine) Glucagon, human H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH Bachem 4033017
Glucagon (Human) His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr ペプチド研究所 4098-s

Gonadorelin (ゴナドレリン)

品名 別名 シークエンス メーカー メーカーコード
LHRH (free acid) trifluoroacetate salt GnRH (free acid), Gonadorelin (free acid), LH-RH, Free Acid Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-OH trifluoroacetate salt Bachem 4009735
(D-Leu7)-LHRH trifluoroacetate salt (D-Leu7)-Gonadorelin Pyr-His-Trp-Ser-Tyr-Gly-D-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt Bachem 4041861
LHRH (1-5) (free acid) trifluoroacetate salt Pyr-His-Trp-Ser-Tyr-OH trifluoroacetate salt Bachem 4028309
LHRH acetate salt Gonadorelin, LH-RH, human, GnRH, Luliberin Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 acetate salt Bachem 4033013
LH-RH (Human) Luteinizing Hormone Releasing Hormone (Human) , Gonadotropin-Releasing Hormone Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 · 2AcOH · 4H2O ペプチド研究所 4013
LH-RH (Human) Luteinizing Hormone Releasing Hormone (Human) , Gonadotropin-Releasing Hormone Pyr-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 ペプチド研究所 4013-v

Goserelin (ゴセレリン):欧州薬局方医薬品各条 (モノグラフ) 掲載

品名 別名 シークエンス メーカー メーカーコード
(D-Ser4,D-Ser(tBu)6,Azagly10)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity A
(D-Ser4)-Goserelin Pyr-His-Trp-D-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 trifluoroacetate salt Bachem 4035304
(Ser(tBu)6,Azagly10)-LHRH
欧州薬局方医薬品各条 (モノグラフ):Impurity B
(Ser(tBu)6)-Goserelin Pyr-His-Trp-Ser-Tyr-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 Bachem 4035307
(Des-Gly10,D-Ser(tBu)6,Pro-NHNH29)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity E
(Pro-NHNH29)-Buserelin, Decarbamoylgoserelin, (Des-carboxamide)-Goserelin Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-NHNH2 trifluoroacetate salt Bachem 4039400
(D-Tyr5,D-Ser(tBu)6,Azagly10)-LHRH
欧州薬局方医薬品各条 (モノグラフ):Impurity F
(D-Tyr5)-Goserelin Pyr-His-Trp-Ser-D-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 Bachem 4035302
(D-His2,D-Ser(tBu)6,Azagly10)-LHRH
欧州薬局方医薬品各条 (モノグラフ):Impurity G
(D-His2)-Goserelin Pyr-D-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 Bachem 4035303
(Ser(Ac)4,D-Ser(tBu)6,Azagly10)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity K
(Ser(Ac)4)-Goserelin Pyr-His-Trp-Ser(Ac)-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 trifluoroacetate salt Bachem 4054732
(D-Ser(tBu)6,D-Leu7,Azagly10)-LHRH
欧州薬局方医薬品各条 (モノグラフ):Impurity L
(D-Leu7)-Goserelin Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-D-Leu-Arg-Pro-Azagly-NH2 Bachem 4037082
(D-Ser(tBu)6,Azagly10)-LHRH acetate salt [DSer(tBu)6, (Aza)Gly10] LH-RH, Goserelin Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Azagly-NH2 acetate salt Bachem 4038252

Histrelin (ヒストレリン)

品名 別名 シークエンス メーカー メーカーコード
(Des-Gly10,D-His2,D-His(Bzl)6,Pro-NHEt9)-LHRH (D-His2)-Histrelin Pyr-D-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt Bachem 4028762
(Des-Gly10,D-His(Bzl)6,Pro-NHEt9)-LHRH acetate salt Histrelin Pyr-His-Trp-Ser-Tyr-D-His(Bzl)-Leu-Arg-Pro-NHEt acetate salt Bachem 4035442

Leuprorelin (リュープロレリン):欧州薬局方医薬品各条 (モノグラフ) 掲載

品名 別名 シークエンス メーカー メーカーコード
(Des-Gly10,D-Ser4,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity A
(D-Ser4)-Leuprolide, (D-Ser4)-Leuprorelin, (Des-Gly10, DSer4, DLeu6, Pro-NHEt9)-LHRH Pyr-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt Bachem 4033803
(Des-Gly10,D-His2,D-Leu6,Pro-NHEt9)-LHRH
欧州薬局方医薬品各条 (モノグラフ):Impurity B
(D-His2)-Leuprolide, (D-His2)-Leuprorelin Pyr-D-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt Bachem 4028311
(Des-Gly10,Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity C
(Leu6)-Leuprolide, (Leu6)-Leuprorelin Pyr-His-Trp-Ser-Tyr-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt Bachem 4033802
(Des-Gly10,Ser(Ac)4,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity D
(Ser(Ac)4)-Leuprolide, (Ser(Ac)4)-Leuprorelin Pyr-His-Trp-Ser(Ac)-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt Bachem 4034724
(Des-Gly10,D-Trp3,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity E
(D-Trp3)-Leuprorelin, (D-Trp3)-Leuprolide Pyr-His-D-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt Bachem 4058815
(Des-Gly10,D-His2,D-Ser4,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity F
(D-His2,D-Ser4)-Leuprorelin, (D-His2,D-Ser4)-Leuprolide Pyr-D-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt Bachem 4048380
(Des-Gly10,D-Tyr5,D-Leu6,Pro-NHEt9)-LHRH
欧州薬局方医薬品各条 (モノグラフ):Impurity G
(D-Tyr5)-Leuprolide, (D-Tyr5)-Leuprorelin Pyr-His-Trp-Ser-D-Tyr-D-Leu-Leu-Arg-Pro-NHEt Bachem 4028312
(Des-Gly10,D-Leu6,D-Leu7,Pro-NHEt9)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity H
(D-Leu7)-Leuprolide, (D-Leu7)-Leuprorelin Pyr-His-Trp-Ser-Tyr-D-Leu-D-Leu-Arg-Pro-NHEt trifluoroacetate salt Bachem 4028310
(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH trifluoroacetate salt
欧州薬局方医薬品各条 (モノグラフ):Impurity I
(D-Pyr1)-Leuprorelin, (D-Pyr1)-Leuprolide D-Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt trifluoroacetate salt Bachem 4046113
(Des-Gly10,D-Leu6,Orn8,Pro-NHEt9)-LHRH trifluoroacetate salt (Orn8)-Leuprorelin, (Orn8)-Leuprolide Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Orn-Pro-NHEt trifluoroacetate salt Bachem 4065128
(Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH acetate salt Leuprolide, Leuprorelin, [Des-Gly10, DLeu6, Pro9] LH-RH, Ethyl Amide Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt acetate salt Bachem 4033014

Octreotide (オクトレオチド)

品名 別名 シークエンス メーカー メーカーコード
Acetyl-Octreotide acetate salt Ac-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol acetate salt (Disulfide bond) Bachem 4071290
(Cys(S)2)-Octreotide trifluoroacetate salt H-D-Phe-Cys(S)-Phe-D-Trp-Lys-Thr-Cys-L-threoninol trifluoroacetate salt (Trisulfide bond) Bachem 4071291
(D-Cys7,des-L-threoninol8)-Octreotide acetate salt H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-D-Cys-OH acetate salt (Disulfide bond) Bachem 4099464
(Des-L-threoninol8)-Octreotide amide acetate salt H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-NH₂ acetate salt (Disulfide bond) Bachem 4099462
(L-Threoninol(Ac)8)-Octreotide acetate salt H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol(Ac) acetate salt (Disulfide bond) Bachem 4099463
(Lys(Ac)5)-Octreotide acetate salt H-D-Phe-Cys-Phe-D-Trp-Lys(Ac)-Thr-Cys-L-threoninol acetate salt (Disulfide bond) Bachem 4099465
Octreotide acetate salt SMS 201-995, (D-Phe5,Cys6.11,D-Trp8,L-Threoninol12)-Somatostatin-14 (5-12) H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol acetate salt (Disulfide bond) Bachem 4042822
Octreotide trifluoroacetate salt (Dimer, Antiparallel) (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol)2 trifluoroacetate salt (Disulfide bonds between Cys2A and Cys7B/Cys7A and Cys2B) Bachem 4080984
Octreotide trifluoroacetate salt (Dimer, Parallel) (H-D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-L-threoninol)2 trifluoroacetate salt (Disulfide bonds between Cys2A and Cys2B/Cys7A and Cys7B) Bachem 4080983

Teriparatide (テリパラチド)

品名 別名 シークエンス メーカー メーカーコード
pTH (2-34) (human) acetate salt H-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH acetate salt Bachem 4069253
pTH (1-34) (human) acetate salt Teriparatide, Parathyroid Hormone (1-34), human H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH acetate salt Bachem 4011474
Parathyroid Hormone (Human, 1-34) PTH (Human, 1-34) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe ペプチド研究所 4068-s
Parathyroid Hormone (Human, 1-34) PTH (Human, 1-34) Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe ペプチド研究所 4068-v

Tetracosactide (Cosyntropin) (テトラコサクチド(コシントロピン))

品名 別名 シークエンス メーカー メーカーコード
(D-Lys16)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt (D-Lys16)-ACTH (1-24) human, bovine, mouse, ovine, porcine, rabbit, rat, (D-Lys16)-Tetracosactide H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-D-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4033149
(D-Ser1)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt (DSer1)-ACTH (1-24) (human, bovine, mouse, ovine, porcine, rabbit, rat), (D-Ser1)-Tetracosactide H-D-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4029278
(Des-Glu5)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt (Des-Glu5)-Tetracosactide H-Ser-Tyr-Ser-Met-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4063587
(Des-His6)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt (Des-His6)-Tetracosactide H-Ser-Tyr-Ser-Met-Glu-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4063586
(Des-Ser3)-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt (Des-Ser3)-Tetracosactide H-Ser-Tyr-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4059984
Endo-4a-Glu-ACTH (1-24) (human, bovine, rat) trifluoroacetate salt Endo-4a-Glu-Tetracosactide H-Ser-Tyr-Ser-Met-Glu-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4063588
ACTH (2-24) (human, bovine, rat) trifluoroacetate salt Corticotropin (2-24), Tetracosactide (2-24) H-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4059983
Acetyl-ACTH (3-24) (human, bovine, rat) trifluoroacetate salt Acetyl-Tetracosactide (3-24) Ac-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4059986
Acetyl-ACTH (7-24) (human, bovine, rat) trifluoroacetate salt Acetyl-Tetracosactide (7-24) Ac-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4062898
ACTH (1-24) (human, bovine, rat) trifluoroacetate salt Cosyntropin, Tetracosactide, Tetracosactrin H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-OH trifluoroacetate salt Bachem 4011958
ACTH (Human, 1-24) Adrenocorticotropic Hormone (Human, 1-24) Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro ペプチド研究所 4109-v

Triptorelin (トリプトレリン)

品名 別名 シークエンス メーカー メーカーコード
(D-Trp6)-LHRH (free acid) trifluoroacetate salt Triptorelin (free acid) Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-OH trifluoroacetate salt Bachem 4026526
(D-Trp6,D-Leu7)-LHRH trifluoroacetate salt (D-Leu7)-Triptorelin Pyr-His-Trp-Ser-Tyr-D-Trp-D-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt Bachem 4025366
(D-Ser4,D-Trp6)-LHRH trifluoroacetate salt (D-Ser4)-Triptorelin Pyr-His-Trp-D-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt Bachem 4025363
(D-Tyr5,D-Trp6)-LHRH trifluoroacetate salt (D-Tyr5)-Triptorelin Pyr-His-Trp-Ser-D-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 trifluoroacetate salt Bachem 4025365
(D-Trp6)-LHRH acetate salt Triptorelin acetate salt, (D-Trp6)-GnRH, [DTrp6] LH-RH, amide Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 acetate salt Bachem 4033016
(D-Trp6)-LHRH pamoate salt Triptorelin pamoate salt Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2 pamoate salt Bachem 4039648

Antazoline (アンタゾリン)

品名 別名 シークエンス メーカー メーカーコード
N-(2-Aminoethyl)-2-(benzylphenylamino)acetamide · maleate N-Aminoethyl-(N-benzylanilino)acetamide · maleate, N-Phenyl-N-Bzl-Gly-2-aminoethylamide · maleate Bachem 4028954
2-(N-Phenyl-N-benzyl-aminomethyl)-imidazole N-Benzyl-N-(1H-imidazol-2-ylmethyl)-aniline, Benzyl-(1H-imidazol-2-ylmethyl)-phenyl-amine Bachem 4052755
Antazoline · 0.5 H2SO4 Benzyl-(4,5-dihydro-1H-imidazol-2-ylmethyl)-phenyl-amine · 0.5 H2SO4 2-(N-Phenyl-N-benzyl-aminomethyl)-imidazoline · 0.5 H2SO4 Bachem 4041457

L-Alanyl-L-Glutamine (L-アラニル-L-グルタミン (静脈栄養))

品名 別名 シークエンス メーカー メーカーコード
H-Ala-D-Gln-OH Bachem 4011868
H-D-Ala-Gln-OH Bachem 4011870
H-Ala-Glu-OH Bachem 4002318
H-Ala-Ala-Gln-OH Bachem 4026080
Cyclo(-Ala-Gln) Bachem 4035535
Cyclo(-Ala-Glu) Bachem 4035536
H-Ala-Gln-OH Bachem 4003766

Aspartame (アスパルテーム):欧州薬局方医薬品各条 (モノグラフ) 掲載

品名 別名 シークエンス メーカー メーカーコード
Cyclo(-Asp-Phe)
欧州薬局方医薬品各条 (モノグラフ):Impurity A
(2S,5S)-5-Benzyl-3,6-dioxo2-piperazineacetic acid, Aspartame-Related Compound A Bachem 4016611
H-Asp-Phe-OH
欧州薬局方医薬品各条 (モノグラフ):Impurity B
Bachem 4001477
H-Phe-OH
欧州薬局方医薬品各条 (モノグラフ):Impurity C
Bachem 4031148
Aspartame H-Asp-Phe-OMe Bachem 4000411

製品一覧

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甘味料 (医薬品添加物)

抗悪性腫瘍薬、性腺刺激ホルモン放出ホルモン受容体作動薬

抗アレルギー薬、ヒスタミンH1受容体拮抗薬

骨吸収抑制薬、骨粗鬆症治療薬、副甲状腺ホルモン受容体作動薬

子宮収縮抑制薬、オキシトシン受容体拮抗薬

静脈栄養

糖尿病治療薬、診断薬、グルカゴン受容体作動薬

糖尿病治療薬、グルカゴン様ペプチド1 (GLP-1) 受容体作動薬

副腎皮質刺激ホルモン

ホルモン分泌抑制薬、ソマトスタチン受容体作動薬

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