Life Science Front line of Neurodegenerative Diseases Research

Vol. 4. Molecular Imaging in Alzheimer's Disease

This article was written by Dr. Makoto Higuchi, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology.

Alzheimer's disease (AD) is neuropathologically characterized by the deposition of protein aggregates and progressive neuronal death in the brain. Pathological protein fibrils deposited in the brain o...

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Life Science

Why are exosomes getting a lot of attention?

First described over 30 years ago, exosomes are now being explored with great interest, particularly regarding their involvement in various diseases and in the development of targeted therapies. Exoso...

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Life Science

Proteome analysis of exosomes

This article was written by Koji Ueda Project for Personalized Cancer Medicine, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Japan.

Exosomes are secretory microvesicles derived from intracellular vesicle trafficking pathways, which are involved in the extracellular release of unwanted molecules or delivery of molecules to distant ...

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Life Science

Protein phosphorylation analysis using Phos-tag-based techniques

This article was written by Emiko Kinoshita-Kikuta, Eiji Kinoshita, Tohru Koike Department of Functional Molecular Science, Institute of Biomedical and Health Sciences, Hiroshima University, Kasumi 1-2-3, Hiroshima, Japan.

Proteins responsible for vital cellular functions use kinase-induced phosphorylation and phosphatase-induced dephosphorylation for their activation and deactivation, respectively. Wide varieties of di...

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