Anti Parvalbumin Antibodies

Parvalbumin (PV), a calcium-binding protein with a low molecular weight of approximately 12 kDa, serves as a marker protein for inhibitory GABAergic interneurons. Fujifilm Wako supplies guinea pig anti-parvalbumin antibodies that are useful for multiplex staining applications.

What is Parvalbumin?

Parvalbumin (PV) is a low-molecular-weight calcium-binding protein, with an approximate molecular weight of 12 kDa, primarily involved in the regulation of intracellular calcium signaling1). It is expressed in muscles and nerves, including various brain regions such as chandelier cells and basket cells in the cerebral cortex, as well as Purkinje cells in the cerebellum2-4).

Parvalbumin is recognized as a marker protein for inhibitory GABAergic interneurons. GABAergic interneurons in the neocortex are broadly classified into three types based on marker protein expression: (1) parvalbumin-positive neurons, (2) somatostatin-positive neurons, and (3) 5HT3a receptor-positive neurons4). Parvalbumin-positive cells are characterized by their rapid firing and repolarization compared to other neurons, and are involved in regulating neurotransmission, neural plasticity, and the formation and maintenance of oscillations5). It is believed that abnormalities in the expression of parvalbumin or parvalbumin-positive neurons may contribute to the development of schizophrenia.

Anti Parvalbumin, Guinea Pig

“Anti Parvalbumin, Guinea Pig” is a guinea pig polyclonal antibody that reacts with PV6). It can be used to perform multiplex immunohistochemistry.

Antibody Information

Clonality Polyclonal
Antigen Recombinant rat parvalbumin
Host Guinea pig
Formulation Antiserum
Conjugate Unconjugated
Cross-reactivity Mouse, Rat
Application Immunohistochemistry (Frozen Section) 1:1,000-3,200

Application Data



Species: Mouse
Site: Sensory cortex
Sample: Frozen section
Antibody concentration: 1:1,500

Data by courtesy of
Dr. Miyata, Department of Applied Biology, Kyoto Institute of Technology


  1. Cates, M. S. et al.: Structure, 7(10), 1269(1999).
    Metal-ion affinity and specificity in EF-hand proteins: coordination geometry and domain plasticity in parvalbumin
  2. Taniguchi, H., Lu, J. and Huang, Z. J.: Science, 339(6115), 70(2013).
    The spatial and temporal origin of chandelier cells in mouse neocortex
  3. Schwaller, B., Meyer, M. and Schiffmann, S.: The cerebellum, 1, 241(2002).
    ‘New’ functions for ‘old’ proteins: The role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice
  4. Rudy, B., Fishell, G., Lee, S. and Hjerling‐Leffler, J.: Dev. Neurobiol., 71(1), 45(2011).
    Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
  5. Ruden, J. B. et al.: Neuropsychopharmacology, 46(2), 279(2021).
    Parvalbumin interneuron vulnerability and brain disorders
  6. Taniguchi, Y. et al.: Cell. Tissue Res., 343, 303(2011).
    Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus

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Anti Parvalbumin, Guinea Pig (Polyclonal Antibody)

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