N,N-Dicyclohexyl-1,3,2-dioxaphospholan-2-amine
- for Nucleic Acid Synthesis
- Manufacturer :
- FUJIFILM Wako Pure Chemical Corporation
- Storage Condition :
- Keep at -20 degrees C.
- CAS RN® :
- 28623-32-7
- Molecular Formula :
- C14H26NO2P
- Molecular Weight :
- 271.34
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1G
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In stock in Japan |
※Check availability in the US with the distributor.
Document
Application
Overview / Applications
| Outline | EDCP (Ethano N,N-dicyclohexylphosphoramidite) is a capping reagent for oligonucleotide synthesis, characterized by low steric hindrance and high reactivity. This reagent was developed by the research group of Professor Yoshiyuki Hari at Tokushima Bunri University. Acetyl protection using acetic anhydride is widely used as a capping reagent. However, acetyl-based capping suffers from the problem of impurity generation due to side reactions, such as substitution reactions with the protecting groups on the nucleobase portion. Furthermore, the acetyl capping reaction has low reactivity with secondary alcohols, such as the hydroxyl group of universal linkers or the 3'-hydroxyl group of nucleic acids. Consequently, unreacted species (uncapped nucleotides) remain, contributing to impurities. This product is a novel capping reagent that avoids impurity issues caused by such side reactions and low reactivity. |
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Manufacturer Information
Alias
- EDCP
Ethano N,N-dicyclohexylphosphoramidite
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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