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Detail Information
  1. Top
  2. Life Science
  3. Physiology Research
  4. Bioactive Peptides
  5. Ion(Ca+, K+, Na+) Channel Blocker
  6. Guangxitoxin-1E

Guangxitoxin-1E

Manufacturer :
Peptide Institute Inc.
Storage Condition :
Keep at -20 degrees C.
Molecular Formula :
C178H248N44O45S7
  • Structural Formula
  • Label
  • Packing
Comparison
Product Number
Package Size
Price
Availability
Certificate of Analysis
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Distributor
334-44331
Manufacturer
4433-s
0.1mg
List Price
248.00 USD

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Document

Package Insert
Spectral Data
Certificate of Analysis
Calibration Certificate
Analytical Charts

Application

Overview / Applications

Outline This product is for research use only. Do not administer it to human.


Kv2.1/Kv2.2 Channel Blocker
Enhancer of Glucose-Dependent Insulin Secretion


Pancreatic β cells respond to glucose, close the ATP-sensitive K+ channel, and increase intracellular Ca2+ to cause insulin secretion. β cells have delayed rectifier K+ channels that play a major role in repolarizing the action potential. Inhibition of these channels increases intracellular Ca2+, causing enhanced insulin secretion. Therefore, delayed rectifier K+ channel blocker has a definite advantage over ATP-sensitive K+ channel blocker in the treatment of type 2 diabetes. Kv2.1 channel, which is a delayed rectifier K+ channel, expresses markedly in β cells. As a result of screening 85 toxicants by an assay system with 86 Rb+ using CHO cells expressed Kv2.1 channels, Guangxitoxin-1E (GxTX-1E, not more than 1 nM of IC50) was found in the Chinese venomous spider, Plesiophrictus guangxiensis sp. nov.

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Manufacturer Information

Alias

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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