Discovery Service of Diverse and High-Affinity Cyclic Peptides
Cyclic peptides are attracting significant attention in drug discovery as a new modality due to their excellent properties such as target specificity, tissue permeability, and synthetic accessibility.
FUJIFILM group offers a variety of contract services to accelerate your peptide drug discovery efforts. For the identification of novel hit peptides that bind to disease targets, we provide screening services based on mRNA display technology.
With this service, a diverse range of hit peptides that strongly bind to target proteins can be obtained from an extensive cyclic peptide library containing unnatural amino acids. During the structural optimization and activity evaluation of these hit peptides, our peptide enzymatic synthesis technology is utilized to facilitate the rapid and comprehensive evaluation, supporting the swift identification of lead peptides with the desired properties.
Peptide discovery services
- Innovative improvements in mRNA display enable screening from >1013 peptides.
- Practical biosynthesis & assays enable rapid selection and activity explorations.
→ Peptides hits with wide varieties and high-affinities can be obtained.
Characteristics of Cyclic peptide with unnatural amino acids
Cyclic peptides with unnatural amino acids have the following characteristics:
- Wide binding capacity and high specificity to undruggable targets.
- Higher stability, lower immunogenicity, and higher tissue permeability than antibodies.
- Being able to be chemically synthesized and be conjugated to other molecules.
Technology①: mRNA display
- Improved mRNA display allows screening from a huge library.
- Many conditions (=cycle size, targets, selections) can be performed in parallel.
→ A variety of hits have been obtained with a high success rate.
Technology②: Biosynthesis & assays
Rapid selection and activity exploration by practical biosynthesis & assay combined with conventional chemical synthesis.
Biosynthesis (in vitro translation): can be synthesized in short time (5~7days) parallelly (>103 peptides can be evaluated in a month)
Result①: Screening of FGFR binding peptides
Diverse binding peptides were successfully obtained toward both of 2 FGFRs (fibroblast growth factor receptor).
Result②: Power of biosynthetic screening
- FGFR activatable peptide had been found through rapid and exhaustive cell activity screening with biosynthetic peptides from diverse hit peptides.
- Optimized peptide showed same cell growth rate with the natural protein (bFGF) in MSC (Mesenchymal Stem Cell).
For research use or further manufacturing use only. Not for use in diagnostic procedures.
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