Fibroblast Growth Factor Chimera (FGFC)
Acidic fibroblast growth factor (FGF1, aFGF) and basic fibroblast growth factor (FGF2, bFGF) are one of the well-known cytokines. These cytokines are known to act on cell growth, differentiation and survival, and have been studied extensively.
This product is a chimeric molecule that combines regions presenting the characteristic activities of FGF1 and FGF2. FGFC acts on a wide range of cells and does not require heparin for its activity. In addition, the presence of acid resistance and protease resistance has been confirmed, solving the problem of in vivo stability that remained a practical weakness of FGF1 use.
One of the original, noteworthy activities of FGF1 is how it defends against radiation damage. Since FGFC has improved in vivo stability, it can be administered to the body in advance to suppress the lethality of high-dose radiation exposure, raising expectations that it can be used to investigate the effects of radiation exposure on the body or to provide a defense mechanism against radiation damage.
Features
- Recombinant protein (expressed in E. coli)
- Binding activity to all FGF receptors from FGFR1 to 4
- Low antigenicity
- Protease resistance, acid resistance
- No heparin required for activation
- Improved stability in the body and in culture media
- Can be added to culture media
- Original activities of FGF1 and FGF2 are retained
Examples of use
Studies of radiation damage
- Effects of radiation on the body
- Defense mechanisms against radiation damage
A substitute for FGF2 (bFGF) (added to iPS cell culture media)
Comparison of FGFC and FGF1/FGF2
| FGFC | FGF1 (aFGF) | FGF2 (bFGF) | ||
| Skin effects | Epidermis | ＋ | ＋ | － |
|---|---|---|---|---|
| Dermis | ＋ | ＋ | ＋ | |
| Stability (in vivo or solution) | High | Low | Low | |
| Decreased activity during preservation in solution | Small | Large | Large | |
| Heparin dependence | No | Yes | No | |
| Loss due to adsorption to container | Less | Much | Much | |
| Production cost of recombinant protein | Low | Middle | High | |
| Total cost | Low | High | High | |
FGFC diagram
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For research use or further manufacturing use only. Not for use in diagnostic procedures.
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