Fibroblast Growth Factor Chimera (FGFC)

Acidic fibroblast growth factor (FGF1, aFGF) and basic fibroblast growth factor (FGF2, bFGF) are one of the well-known cytokines. These cytokines are known to act on cell growth, differentiation and survival, and have been studied extensively.

This product is a chimeric molecule that combines regions presenting the characteristic activities of FGF1 and FGF2. FGFC acts on a wide range of cells and does not require heparin for its activity. In addition, the presence of acid resistance and protease resistance has been confirmed, solving the problem of in vivo stability that remained a practical weakness of FGF1 use.

One of the original, noteworthy activities of FGF1 is how it defends against radiation damage. Since FGFC has improved in vivo stability, it can be administered to the body in advance to suppress the lethality of high-dose radiation exposure, raising expectations that it can be used to investigate the effects of radiation exposure on the body or to provide a defense mechanism against radiation damage.


  • Recombinant protein (expressed in E. coli)
  • Binding activity to all FGF receptors from FGFR1 to 4
  • Low antigenicity
  • Protease resistance, acid resistance
  • No heparin required for activation
  • Improved stability in the body and in culture media
  • Can be added to culture media
  • Original activities of FGF1 and FGF2 are retained

Examples of use

Studies of radiation damage

  • Effects of radiation on the body
  • Defense mechanisms against radiation damage

A substitute for FGF2 (bFGF) (added to iPS cell culture media)

Comparison of FGFC and FGF1/FGF2

Skin effects Epidermis
Stability (in vivo or solution) High Low Low
Decreased activity during preservation in solution Small Large Large
Heparin dependence No Yes No
Loss due to adsorption to container Less Much Much
Production cost of recombinant protein Low Middle High
Total cost Low High High

FGFC diagram

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FGF1, Recombinant

FGF2, Recombinant

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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