This compound is a cyclic depsipeptide isolated from the soil bacterium Chromobacterium QS3666 strain.
Among the Gq family of trimeric G proteins, it specifically inhibits signals mediated through Gαq, Gα11, and Gα14 (among about 20 varieties of G protein, those involved in increasing Ca ion concentration) by acting on the GDP/GTP exchange reaction.
This compound is the first membrane-permeable compound that selectively inhibits Gq signals, and will become a useful tool in Gq signal analysis studies.
- Specifically inhibits signals mediated through Gαq, Gα11, and Gα14
- Membrane-permeable, low-molecular-weight compound
- Acts in both in vivo and in vitro systems
○ CAS RN® 568580-02-9
○ Purity： ≥ 95.0 %
○ How to use： Dissolve in DMSO to a concentration of 1 to 10 mmol/L to make a stock solution. Prior to use, dilute appropriately with the solution of the experimental system.
*Stock solutions should be used as soon as possible.
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For research use or further manufacturing use only. Not for use in diagnostic procedures.
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