Parkinson's Disease-related Antibodies
Phosphorylated α-Syn Antibody
| Phosphorylated α-Synuclein, Monoclonal Antibody | ||||||
| Cat. No. | Product Name | Grade | Package Size | |||
|---|---|---|---|---|---|---|
| 015-25191 | Anti Phosphorylated α-Synuclein, Monoclonal Antibody (pSyn#64) | For immunochemistry | 50 µL | |||
| Antibody Information | ||||||
| Antigen | α-Synuclein pS129 | Application | WB, IHC | Isotype | IgG | ■Immunostaining image Brain section of dementia with Lewy bodies  Courtesy of Iwatsubo,T., Graduate School of Medicine, The University of Tokyo |
| Antigen information | Amino acid residue 124-134 of human α-synuclein with phosphorylated serine at position 129 | Species cross reactivity | Human, Mouse, Rat | Label | Unlabeled | |
| Antigen synonyms | SNCA, PARK1, PARK4, NACP, PD1 | Host | Mouse | Clone No. | pSyn#64 | |
| Summary | Lewy body, a substance specifically found in nerve cells affected with Parkinson’s disease or dementia with Lewy body (DLB), contains α-synuclein protein of which serine at 129th position is specifically phosphorylated. This antibody does not react with normal α-synuclein, but recognizes only accumulated phosphorylated α-synuclein. This antibody is available for research in the Lewy body-related pathology. | |||||
| Reference | 1) Fujiwara. H., et al,.: Nature Cell Biology, 4, 160 (2002). 2) Saito. Y,.: Journal of Neuropathology and Experimental Neurology, 62, 644 (2003). |
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| Biotin conjugated Phosphorylated α-Synuclein, Monoclonal Antibody | ||||||
| Cat. No. | Product Name | Grade | Package Size | |||
|---|---|---|---|---|---|---|
| 010-26481 | Anti Phosphorylated α-Synuclein, Monoclonal Antibody (pSyn#64), Biotin-conjugated | For immunochemistry | 100 µL | |||
| Antibody Information | ||||||
| Antigen | α-Synuclein pS129 | Application | IHC, ICC | Isotype | IgG | ■Immunostaining image Mouse brain section  Courtesy of Kuwabara and Iwatsubo, Graduate School of Medicine, The University of Tokyo |
| Antigen information | Amino acid residue 124-134 of human α-synuclein with phosphorylated serine at position 129 | Species cross reactivity | Human, Mouse, Rat | Label | Biotin | |
| Antigen synonyms | SNCA, PARK1, PARK4, NACP, PD1 | Host | Mouse | Clone No. | pSyn#64 | |
| Summary | This is an biotin-conjugated antibody of above Anti Phosphorylated α-Synuclein, Monoclonal Antibody (pSyn#64) (Wako Cat. No. 015-25191). | |||||
Parkin Antibody
| Cat. No. | Product Name | Grade | Package Size | |||
|---|---|---|---|---|---|---|
| 010-27341 | Anti Parkin, Monoclonal Antibody (Par6) | For immunochemistry | 10 µL | |||
| 016-27343 | 50 µL | |||||
| Antibody Information | ||||||
| Antigen | Parkin | Application | WB | Isotype | IgG2·κ | ■WB image
Lane1: Rat brain lysate
Lane2: Mouse brain lysate Lane3: PC12 cell Lane4: Hela cell Lane5: HEK293T cell Lane6: HEK293T cell express Human Parkin |
| Antigen information | Full length recombinant human Parkin | Species cross reactivity | Human, Mouse, Rat | Label | Unlabeled | |
| Antigen synonyms | PRKN, Parkin RBRE4 ubiquitin protein ligase | Host | Mouse | Clone No. | Par6 | |
| Summary | Parkin is an ubiquitin protein ligase about 50kDa that is a 465 amino acid with N-terminal ubiquitin-like domain. Parkin is a familial Parkinson disease (PD) gene product. PD is one of the most frequency neurodegenerative diseases. This item is a mouse monoclonal antibody which reacts with Parkin. | |||||
| Reference | － | |||||
Autophagy related Antibody
| Autophagy related Antibody, Atg7 | ||||||
| Cat. No. | Product Name | Grade | Package Size | |||
|---|---|---|---|---|---|---|
| 013-22831 | Anti Human Atg7, Rabbit | For immunochemistry | 50 µL | |||
| Antibody Information | ||||||
| Antigen | Atg7 | Application | WB | Isotype | IgG | ■WB Lysate of Mouse MEF  Courtesy of Ueno, T., Juntendo University School of Medicine |
| Antigen information | KLH-conjugated Human Atg7 aa 556-571 | Species cross reactivity | Human, Rat, Mouse | Label | Unlabeled | |
| Antigen synonyms | APG7L, GSA7 | Host | Rabbit | Clone No. | Polyclonal | |
| Summary | Atg7 is an essential factor to assemble autophagosomes during the process of autophagy. It is an E1-like enzyme that binds to ubiquitin-like proteins Atg8 and Atg12. Dysfunction of Autophagy factors have been reported in neurodegenerative diseases such as Parkinson’s disease. | |||||
| Reference | － | |||||
| Autophagy related Antibody, LC3 | ||||||
| Cat. No. | Product Name | Grade | Package Size | |||
|---|---|---|---|---|---|---|
| 010-22841 | Anti Rat LC3, Rabbit | For immunochemistry | 50 µL | |||
| Antibody Information | ||||||
| Antigen | LC3 | Application | WB, ICC | Isotype | IgG | ■Immunostaining image Hela cells  Courtesy of Kikkawa, M., Juntendo University Graduate School of Medicine |
| Antigen information | KLH conjugated LC3B aa 5-18 | Species cross reactivity | Human, Rat, Mouse | Label | Unlabeled | |
| Antigen synonyms | LC3B, MAP1LC3B, ATG8F, MAP1ALC3 | Host | Rabbit | Clone No. | Polyclonal | |
| Summary | LC3 is a mammalian analogue of Atg8 essential factor of autophagy in budding yeast. LC3 become LC3-I by removing C-terminal shortly after synthesis in cytoplasm. It is passed to E1-like enzyme (Atg7) and E2-like enzyme (Atg3) and it become LC3-II by binding with phospholipid. LC3-II bind to autophagosome membrane. This is why LC3 is used as a marker of autophagy. Dysfunction of autophagy factors have been reported in neurodegenerative diseases such as Parkinson’s disease. This antibody recognize both LC3-I and LC3-II. | |||||
| Reference | － | |||||
| Autophagy related Antibody, SQSTM1/A170/p62 | ||||||
| Cat. No. | Product Name | Grade | Package Size | |||
|---|---|---|---|---|---|---|
| 018-22141 | Anti SQSTM1/A170/p62, Rabbit | For immunochemistry | 100 µL | |||
| Antibody Information | ||||||
| Antigen | SQSTM1, A170, p62 | Application | WB, IHC, IF | Isotype | IgG | ■Immunostaining image Rat basal ganglion  Courtesy of Nakaso, K., Faculty of Medicine, Tottori University |
| Antigen information | Mouse SQSTM1/A170/p62 PEST domain (T7 tag + amino acid 254-333 + His tag) recombinant | Species cross reactivity | Rat, Mouse | Label | Unlabeled | |
| Antigen synonyms | Sequestosome 1, OSIL, PDB3, ZIP3, EBIA, PORCA, p62B | Host | Rabbit | Clone No. | Polyclonal | |
| Summary | Sequestosome 1(SQSTM1)/A170(Mouse )/p62(human)/ZIP (Rat) is a ubiquitin binding protein and shows oxidative stress-dependent expression. Recently, it is reported that SQSTM1 binds to LC3, an autophagy related factor. It attracts attention because it may induce protein degradation from ubiquitin/proteosome system to autophagy system. In neurodegenerative diseases including Parkinson’s disease, dysfunction of autophagy factor is implicated. | |||||
| Reference | Ishii, T., et al.: J. Biol. Chem., 275, 16023 (2000). | |||||
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