Anti IDH2, Monoclonal Antibody (RMab-22)

for Immunochemistry

Manufacturer :: FUJIFILM Wako Pure Chemical Corporation

Storage Condition :: Keep at -20 degrees C.

Host :: Mouse
Clone No. :: RMab-22

Classification :: Monoclonal

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Comparison	Product Number	Package Size	Price	Inventory
	Distributor 011-24071 Barcode No 4548995002594	100ug	List Price JPY 44,100	In stock in Japan	Certificate of Analysis

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Antibody Information
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Spectral Data

Certificate of Analysis

100ug

Calibration Certificate

Overview / Applications

Outline	This product is for research use only. Do not administer it to human.In humans, IDH1, IDH2, and IDH3 subtypes are known for isocitrate dehydrogenase (IDH). Of these, IDH1 and IDH2 point mutations are often seen in glioma of WHO grade II and III or glioblastoma of Grade IV (from a lower grade glioma; secondary glioblastoma). This product is for research use only. Do not administer it to human. Isocitrate dehydrogenases (IDHs) play an important role of the enzymes in the TCA cycle. IDH1 and IDH2 are NADP⁺-dependent forms. They are located in cytoplasm (IDH1) and in mitochondria (IDH2), respectively. Recent studies have reported that IDH mutations were specifically found in several types of glioma. Among them, the most frequent mutation is arginine 132 residue (R132) in IDH1 and R172 in IDH2. There are several IDH1 mutations including R132H, R132S, R132G, R132C and R132L. This Anti IDH2, Monoclonal Antibody is available to detect wild type and mutated IDH2. Description Reactivity: Reacts with wild type and mutated IDH2 Species cross reactivity: Human, Mouse, Hamster Clone No.: RMab-22 Host: Mouse Isotype: IgG2b Source: Purified from hybridoma supernatant using protein G agarose Concentration: Indicated on each label Formulation: PBS (pH 7.2) containing 0.05% sodium azide Applications ELISA: 1 - 5 μg/mL Western Blot: 5 μg/mL Immunohistochemistry: 5 - 10 μg/mL Note Avoid repeated the freeze and thaw cycle.

Outline

This product is for research use only. Do not administer it to human.In humans, IDH1, IDH2, and IDH3 subtypes are known for isocitrate dehydrogenase (IDH). Of these, IDH1 and IDH2 point mutations are often seen in glioma of WHO grade II and III or glioblastoma of Grade IV (from a lower grade glioma; secondary glioblastoma).
This product is for research use only. Do not administer it to human.

Isocitrate dehydrogenases (IDHs) play an important role of the enzymes in the TCA cycle. IDH1 and IDH2 are NADP⁺-dependent forms.
They are located in cytoplasm (IDH1) and in mitochondria (IDH2), respectively. Recent studies have reported that IDH mutations were specifically found in several types of glioma. Among them, the most frequent mutation is arginine 132 residue (R132) in IDH1 and R172 in IDH2. There are several IDH1 mutations including R132H, R132S, R132G, R132C and R132L.
This Anti IDH2, Monoclonal Antibody is available to detect wild type and mutated IDH2.

Description
Reactivity: Reacts with wild type and mutated IDH2
Species cross reactivity: Human, Mouse, Hamster
Clone No.: RMab-22
Host: Mouse
Isotype: IgG2b
Source: Purified from hybridoma supernatant using protein G agarose
Concentration: Indicated on each label
Formulation: PBS (pH 7.2) containing 0.05% sodium azide

Applications
ELISA: 1 - 5 μg/mL
Western Blot: 5 μg/mL
Immunohistochemistry: 5 - 10 μg/mL

Note
Avoid repeated the freeze and thaw cycle.

Property

Antibody Information

Antigen	IDH2
Antigen Alias	isocitrate dehydrogenase 2 (NADP+), mitochondrial ICDM, IDH, IDHM, IDP, mNADPIDH IDH2 IDH2 - isocitrate dehydrogenase 2 (NADP+), mitochondrial
Subclass	IgG2b

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Related Information

Product List

Product Name
Anti ATRX, Monoclonal Antibody (AMab-6)	for Immunochemistry
Anti TERT, Monoclonal Antibody (TMab-6)	for Immunochemistry
Anti IDH1-R132H, Monoclonal Antibody (HMab-1)	for Immunochemistry
Anti IDH1-R132H, Monoclonal Antibody (HMab-2)	for Immunochemistry
Anti IDH1-R132S, Monoclonal Antibody (SMab-1)	for Immunochemistry
Anti IDH1, Monoclonal Antibody (RMab-3)	for Immunochemistry
Anti Mutated IDH1/2, Monoclonal Antibody (MsMab-1)	for Immunochemistry

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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