Anti CX3CR1 Antibodies

CX3C motif chemokine receptor 1 (CX3CR1) is a receptor for CX3CL1, also known as fractalkine, and belongs to the G protein-coupled receptor (GPCR) family. In peripheral tissues, CX3CR1 is primarily expressed on the surface of macrophages, lymphocytes, and dendritic cells, and it participates in processes such as cell survival, proliferation, adhesion, and migration. In the central nervous system (CNS), CX3CR1 is predominantly expressed in microglia and macrophages, playing a role in the development and maintenance of homeostasis within the CNS.

What is CX3CR1?

CX3CR1 is a receptor for CX3CL1, also known as fractalkine, and belongs to the GPCR family. In peripheral tissues, CX3CR1 is primarily expressed on the surface of macrophages, lymphocytes, and dendritic cells, and it participates in processes such as cell survival, proliferation, adhesion, and migration.

In the CNS, CX3CR1 is predominantly expressed in microglia and macrophages, serving as a marker for these cells. It plays a role in the development and maintenance of homeostasis within the CNS1). Notably, CX3CR1 knockout mice exhibit deficits in synaptic pruning by microglia, leading to abnormalities in synaptic transmission between neurons. This suggests that CX3CR1 is critical for synaptic pruning2).

Anti CX3CR1, Guinea Pig

Anti CX3CR1, Guinea Pig is a polyclonal antibody against CX3CR1, derived from guinea pigs3-4). It is suitable for use in multiplex immunohistochemical staining.

Antibody Information

Clonality Polyclonal
Antigen CX3CR1 synthetic peptide (corresponding to N-terminal sequence)
Host Guinea Pig
Formulation PBS, 0.1% sodium azide
Conjugate Unconjugated
Cross-reactivity Mouse, Rat
Application IHC (frozen section) 1:800-1,600

Application Data

Immunohistochemistry

Immunohistochemistry
Species
Mouse
Site
Hippocampus
Sample
Frozen section
Primary antibody
Anti Iba1, Rabbit (for Immunocytochemistry)
(Product Number 019-19741) 1:500
Anti CX3CR1, Guinea Pig (this product) 1:800

NeuroTrace™435/455 Blue Fluorescent Nissl Stain (ThermoFisher Scientific, Inc.) was used for staining neurocytes.

[Data by courtesy of]
Dr. Miyata, Department of Applied Biology, Kyoto Institute of Technology

References

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Anti CX3CR1, Guinea Pig

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Anti Iba1 Antibodies

Microglia Depletion Reagents

For research use or further manufacturing use only. Not for use in diagnostic procedures.

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