Anti Asialo GM1 Antibodies

The glycolipid asialo ganglioside-GM1 (ASGM1) is expressed by T cells in viral infection and by natural killer (NK) cells. ASGM1 is localized in lipid raft structures in NK and CD8(+) T cells. Anti asialo GM1 antibody reduces natural killer (NK) activity in cells of various strains of mice and rats.
To investigate the function of NK cells, or transplant tumor tissue derived from the other species to mice, Anti asialo GM1 antibody is injected to remove NK cells¹⁾²⁾.
Recently, it is reported that ASGM1 is also expressed by Basophils, and Anti asialo GM1 antibody is able to remove Basophils too³⁾.

Features

• Tested the anti NK cells activityin vivo
• Used in many papers

References

1. Kasai M., Iwamori M., Nagai Y., Okumura K., and Tada T. : J. Immunol., 10, 175 (1980).
2. Habu S., Fukui H., Shimamura M., Kasai M., Nagai Y., Okumura K., and Tamaoki N. : J. Immunol., 127, 34 (1981).
3. Hideto, N., Kaori, M., Yohei, K., Yoshiyuki, M., and Hajime K., .: J. Immunol., 186, 10, 5766(2011).

Our Anti asialo GM1 used in many papers as follows;

• Hudson, W. A., Li, Q., Le, C., and Kersey, J. H., : Leukemia, 12, 2029 (1998).
• Murphy W. J., Durum S. K., Longo D. L., : PNAS, 89, 10, 4481 (1992).
• Bentzmann S., Roger P., Dupuit F., Bajolet-Laudinat O., Fuchey C., Plotkowski C. M., Puchelle E. : Infection and immunity, 64, 5, 1582 (1996).
• Nishikado H., Mukai K., Kawano Y., Minegishi Y., Karasuyama H. : J. Immunol., 186, 10, 5766(2011).
• Victorino, F., Sojka, K. D., Brodsky, S. K. McNamee, N. E., Masterson, C. J., Homann, D., Yokoyama, M. W., Eltzschig, K. H., Clambey, T. E., : J. Immunol., 195, 10, 4973(2015).

List of abbreviations representing applications