Anti Asialo GM1 Antibodies
Anti asialo GM1, rabbit
The glycolipid asialo ganglioside-GM1 (ASGM1) is expressed by T cells in viral infection and by natural killer (NK) cells. ASGM1 is localized in lipid raft structures in NK and CD8(+) T cells. Anti asialo GM1 antibody reduces natural killer (NK) activity in cells of various strains of mice and rats.
To investigate the function of NK cells, or transplant tumor tissue derived from the other species to mice, Anti asialo GM1 antibody is injected to remove NK cells1)2).
Recently, it is reported that ASGM1 is also expressed by Basophils, and Anti asialo GM1 antibody is able to remove Basophils too3).
| ● Contents | Rabbit anti asialo GM1, lyophilized |
| ● Preparation | GM1 from bovine brain tissue was repeatedly immunized with methylated bovine serum albumin and with complete Freund’s adjuvant. |
| ● Purification | Gammaglobulin fraction of serum was obtained by 50% ammonium sulfate precipitation methods followed by dialyzing with phosphate buffered saline (pH7.2). |
| ● Specificity | React with mouse and rat natural killer cells, mouse monocytes and fetal thymocytes. |
| ● Reconstitution | Reconstitute with 1 mL of distilled water. For dilution, phosphate buffer (pH7.2) is recommended. |
| ● Injection | Inject to mouse 10-50μL intravenously. |
Features
- Tested the anti NK cells activityin vivo
- Used in many papers
References
- Kasai M., Iwamori M., Nagai Y., Okumura K., and Tada T. : J. Immunol., 10, 175 (1980).
- Habu S., Fukui H., Shimamura M., Kasai M., Nagai Y., Okumura K., and Tamaoki N. : J. Immunol., 127, 34 (1981).
- Hideto, N., Kaori, M., Yohei, K., Yoshiyuki, M., and Hajime K., .: J. Immunol., 186, 10, 5766(2011).
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