Silica-SMAP

Cross-coupling with Ar-Cl¹⁾

Suzuki-Miyaura cross-coupling reaction of aryl chloride is proceeded with good yield.

Borylation of Ar-Cl with bulky substituents¹⁾

The borylation of aryl chloride having bulky substituents is also successful.

Comparison of Silica-SMAP with Buchwald’s ligand¹⁾

ortho-Regioselective reaction of C-H borylation^{2), 4)}

Residual heavy metals after reaction¹⁾

There is reported that residual heavy metals after catalytic reaction using Silica-SMAP, for example Pd and Rh, was lower than detection limit by ICP-AES analysis.

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3. Kawamorita, S., Miyazaki, T., Ohmiya, H., Iwai, T. and Sawamura, M. : J. Am. Chem. Soc., 133, 19310 (2011).
4. Hamasaka, G., Ochida, K., Hara, K., and Sawamura, M. : Angew. Chem. Int. Ed., 46, 5381 (2007).