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High Boiling Point Cyclic Ether

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This product is a solvent of hydrophobic cyclic ether. It is available for various organic synthesis reactions such as reactions with organometallic compounds or as a solvent for polymerization. In addition, the operability after reactions is good with easy to separate from water.

CAS:4717-96-8
C6H12O = 100.16
Boiling point: 105℃

Feature

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  • Separable for water and MTHP.
  • Similar solubitlity as THF.
  • Stable for acid and base.
  • Stable for oranometallic reagents (e.g. Grignard Reagent, Lithium reagent.)
  • Lower volatility (105℃) than THF (65℃) and 2-Mr-THF (80℃).

Physical Properties

b.p.
(℃)
m.p.
(℃)
Specific gravity
(20℃)
Viscosity
(cP)
Flash point
(℃)
Solubility
in water (wt%)
Moisture Azeotropic point
(℃, water)
SPvalue* (cal/cm3^0.5)
MTHP 105 <-70 0.86 0.78 6.5 1.5 1.4 84.5 (19.0wt%) 9.0
THF 65 -109 0.89 0.55 -15 64 (6.0wt%) 9.5
2MTHF 80 -136 0.85 0.60 -11 14 4.4 88 (15wt%) 8.9
CPME 106 <-140 0.86 0.55 -1.0 1.1 0.3 83 (16.3wt%) 8.4
Et2O 34.6 - 0.70 0.71 -45 6.5 1.2 34.2 (1.3wt%) 7.6
1,4-dioxane 101 12 1.04 1.30 11 87.8 (18.4wt%) 10.0

*Calculated according to Hansen solubility parameters a user's handbook 2nd edition, CRC Press, ISBN:0-8493-7248-8


under acidic conditions under basic conditions
20% HCl aq./solvent = 1/1(wt%), 50℃ 20% NaOH aq./solvent = 1/1(wt%), 50℃
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Example

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Reference

  1. Onoe, M., Baba, K., Kim, Y., Kita, Y., Tobisu, M. and Chatani, N.: J. Am. Chem. Soc., 134, 19477 (2012).
  2. Iyanaga, M., Aihara, Y, and Chatani, N.: J. Org. Chem., 79, 11933 (2014).

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