薬理試験

HPLCを用いた神経伝達物質　依頼分析

HPLCを用いた「神経伝達物質」をメインターゲットとした分析をお受けさせて頂いております。
一般的なHPLC-UVおよび蛍光検出器ではなく「電気化学検出器」を用いることで10倍以上の高感度分析を得意としています。

エイコム依頼分析

生体内の微量な神経伝達物質の測定
これまでにご依頼いただいたことのある分析の一例
分析装置
実験例
脳以外への応用部位
サンプリング形状
HTEC シリーズを用いたアプリケーションノート（簡易版）
関連した文献
お見積り・ご注文について
関連サービス

生体内の微量な神経伝達物質の測定

エイコムでは、これまで蓄積してきたノウハウを使い電気化学検出器を主軸とした自社の分析機器を用いて分析・サービスを行っています。お客様のニーズに応じアプリケーション、分析システムを選択し高付加価値なサポートを致します。

脳関連の研究（うつ、アルツハイマー、パーキンソンなど）
血液および尿中の成分分析（癌マーカー、薬の血中濃度など）
筋肉や臓器から放出される成分分析
細胞から放出される成分分析（iPS細胞など）
抗酸化の研究（加齢、衛生など）

これまでにご依頼いただいたことのある分析の一例

脳脊髄液　セロトニン
脳脊髄液　モノアミン
血中　カテコールアミン
モノアミンおよび代謝物
脳ホモジ　アセチルコリン
血漿　NOx
ビタミン C
マイクロダイアリシス　アミノ酸
マイクロダイアリシス　DL アラニン
グリシン、グルタミン酸
キサンツレン酸
マイクロダイアリシス　GABA
細胞培養液　ドーパミン
脳ホモジ　メラトニン
脳ホモジ　セロトニン、ドーパミン
血清　MHPG
脊髄液　ノルアドレナリン、ドーパミン、セロトニン
ニトロチロシン
皮下マイクロダイアリシス　ノルアドレナリン
血清　キヌレニン、セロトニン、トリプトファン
腎臓ホモジ　ノルアドレナリン
側坐核　ドーパミン

分析装置

システム構成のイメージ

HPLC 機器を使用した　蛍光検出器、UV 検出器、電気化学検出器（ECD）で分析可能な物質であれば、ぜひご相談下さい。

電気化学検出器(ECD)※1

フローセル※2

実験例

マイクロダイアリシスとのコンビネーション実験

オープンフィールド

Morris水迷路、強制水泳

トレッドミル

高架式十字迷路

スキナー箱

その他いろいろ・・・
オプトジェネティクス
呼気ガスとの同時測定
薬物の同時投与

フリームービング回収　流路図（マイクロダイアリシス法）

脳以外への応用部位

脊髄：脊髄損傷の研究

筋肉：スポーツ科学（運動と生理）

皮下：塗薬がどれぐらい皮下へ浸透しているか

臓器（腸、心臓、唾液腺など）：口から投与した薬がどれぐらい末梢神経まで到達しているか
薬の影響で臓器内での物質がどれぐらい増減したか

サンプリング形状

脳組織
脳組織・ホモジネート
血清
血漿
尿
細胞培養液

HTEC シリーズを用いたアプリケーションノート（簡易版）

関連した文献

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HPLCを用いた神経伝達物質 依頼分析