Anti Laminin Antibodies

Laminin is a glycoprotein that constitutes the extracellular matrix (ECM) and plays an important role in cell adhesion, migration, and proliferation. In particular, laminin, together with type IV collagen, is a major component of the basement membrane. Fujifilm Wako offers guinea pig anti-laminin antibodies that are useful for multiplex staining.

What is Laminin?

ラミニンの基本構造

Basic Structure of Laminin

Created based on Ref. 1)

Laminin is a glycoprotein with a molecular weight of approximately 900 kDa. It consists of three chains-α, β, and γ-that assemble into a cross-shaped structure. Each chain has multiple isoforms, and laminin types are named based on the combination of isoforms (for example, laminin composed of α1/β1/γ1 is referred to as laminin-111).

Laminin is well-known as a key component of the extracellular matrix (ECM) and plays an important role in cell adhesion, migration, and proliferation. In particular, laminin, together with type IV collagen, is considered a major component of the basement membrane. In the central nervous system, laminin is almost exclusively expressed in the basement membranes surrounding blood vessels and is used as a marker for these vessels. Previous studies have shown that the inner (endothelial) layer of the basement membrane in blood vessels contains laminin-411 and -511, while the outer (parenchymal) layer contains laminin-211 and -1111). Laminin also plays a critical role in the formation and function of the blood-brain barrier (BBB).

Anti Laminin, Guinea Pig

The “Anti Laminin , Guinea Pig” is a guinea pig polyclonal antibody, raised against Laminin2-6). It can be used to perform multiplex immunohistochemistry.

Antibody Information

Clonality Polyclonal
Antigen Laminin isolated from Engelbreth-Holm-Swarm murine sarcoma basement membrane
Host Guinea pig
Formulation Antiserum diluted in PBS
Conjugate Unconjugated
Cross-reactivity Mouse, Rat
Application Immunohistochemistry (Frozen Section) 1:500 * 6 hours of post-fixation is recommended

Application Data

Immunohistochemistry

Immunohistochemistry

Species: Mouse
Site: Hippocampus
Sample: Frozen section
Antibody concentration: 1:500

Data by courtesy of
Dr. Miyata, Department of Applied Biology, Kyoto Institute of Technology

免疫組織染色

Species: Mouse
Site: Medulla oblongata (Area postrema)
Sample: Frozen section
Antibody concentration: 1:500

Data by courtesy of
Dr. Miyata, Department of Applied Biology, Kyoto Institute of Technology

References

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Anti Laminin, Guinea Pig (Polyclonal Antibody)

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Anti Iba1 Antibodies

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